52056-71-0Relevant academic research and scientific papers
PYRIDINEDIONE CARBOXAMIDE INHIBITORS OF ENDOTHELIAL LIPASE
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Paragraph 00168, (2013/04/13)
The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.
THIO- AND OXO-ACIDS OF TRICOORDINATED SULFUR: SYNTHETIC AND STEREOCHEMICAL ASPECTS
Drabowicz, Jozef,Lyzwa, Piotr,Bujnicki, Bogdan,Mikolajczyk, Marian
, p. 293 - 312 (2007/10/02)
This account describes the first synthesis, characterization and reactivity of the relatively stable thiosulfinic acid salts.New approaches for the preparation of optically active sulfinic acid salts and sulfones, which are chiral due to 16O, 18O isotopic substitution, as well as measurement of their chirooptical properties are also presented.Key words: thiosulfinic acid salts, chiral 16O, 18O-sulfinic acids salts, sulfinyl chlorides, optically active sulfoxides, optically active 16O, 18O-sulfones, optical activity, circular dichroism.
ORGANOSULPHUR COMPOUNDS-LXIX OPTICALLY ACTIVE SULPHINATES: A NEW TYPE OF ENANTIOSELECTIVE ASYMMETRIC SYNTHESIS AND KINETIC RESOLUTION
Drabowicz, Jozef,Legedz, Slawomir,Mikolajczik, Marian
, p. 5243 - 5252 (2007/10/02)
Optically active sulphinates with the sulphur atom as a sole centre of chirality are prepared by two methods.The first involves the reaction of symmetrical sulphites with tert-butylmagnesium chloride in the presence of optically active aminoalcohols.This new asymmetric, enantioselective synthesis affords t-butylsulphinates with 40-70percent enantiomeric excess values.The second approach is based on a new type of kinetic resolution taking place when racemic sulphinates are reacted with tert-butylmagnesium chloride complexed by optically active alkaloid bases.Both the recovered sulphinates and sulphoxides formed in this reaction show moderate optical purities.
