52147-07-6Relevant academic research and scientific papers
Improved Buchner reaction selectivity in the copper-catalyzed reactions of ethyl 3-arylmethylamino-2-diazo-3-oxopropanoates
Liu, Jing,Tu, Jianzhuo,Yang, Zhanhui,Pak, Chol-Ung,Xu, Jiaxi
, p. 4616 - 4626 (2017/07/11)
Ethyl 3-alkyl(arylmethyl)amino-2-diazo-3-oxopropanoates (diazo amidoacetates) generate generally both cyclohepta[c]pyrrolones (Buchner products) and β-lactams (1,4-insertion products), and show obvious N-substituent-controlled chemoselectivity between the intramolecular Buchner reaction and aliphatic 1,4-C-H insertion under the catalysis of copper salts. The less steric N-alkyl substituents in the amide moiety generally favor the aliphatic 1,4-C-H insertion, while the more steric N-alkyl substituents generally favor the Buchner reaction. Compared with rhodium and ruthenium-catalyzed conditions, the current copper-catalyzed conditions improved the Buchner reaction selectivity of ethyl 3-alkyl(arylmethyl)amino-2-diazo-3-oxopropanoates.
Chemical and pharmacological research on derivatives of 1H naphtho(2,1 b)pyran. I: Synthesis of 1 oxo 3 dialkylamino 1H naphtho(2,1 b)pyrans
Ermili,Roma,Mazzei,et al.
, p. 225 - 236 (2007/10/10)
Synthesis and pharmacologic properties of 1H naphtho[2,1 b]pyran derivatives are discussed. Reaction of N,N dialkylethoxycarbonylacetamides with β naphthol in the presence of phosphorus oxychloride afforded 3 dialkyl 1 oxo amino 1H naphtho[2,1 b]pyrans. Some of these compounds showed pharmacologic activity on the CNS. The 3 dimethylamino (K8291), 3 N(N methyl,N ethyl)amino (K8409), 3 dipropylamino (K8404) and 3 (N piperidyl) (K8294) derivatives have anticonvulsant and sedative activities.
