52252-80-9Relevant academic research and scientific papers
A concise approach to polysubstituted oxazoles from N-acyl-2-bromo enamides via a copper(i)/amino acid-catalyzed intramolecular C-O bond formation
Liu, Bingjie,Zhang, Yueteng,Huang, Gang,Zhang, Xinting,Niu, Pengfei,Wu, Jie,Yu, Wenquan,Chang, Junbiao
, p. 3912 - 3923 (2014/06/09)
A straightforward and efficient copper(i)/amino acid-catalyzed intramolecular Ullmann-type C-O coupling reaction has been developed. This protocol affords a facile methodology for the synthesis of a series of novel 2,4,5-substituted oxazoles from readily accessible N-acyl-2-bromo enamides under mild conditions. This journal is the Partner Organisations 2014.
Copper(II)-mediated cascade oxidative C-C coupling and aromatization: Synthesis of 3-hydroxyphenanthridinone derivatives
Yu, Qingzhen,Zhang, Nan,Tang, Yang,Lu, Hang,Huang, Jianhui,Wang, Songqing,Du, Yunfei,Zhao, Kang
supporting information; experimental part, p. 2374 - 2384 (2012/09/07)
A novel copper(II) acetate mediated synthesis of 3-hydroxyphenanthridin- 6(5H)-ones from N-(3-oxocyclohex-1-enyl)benzamides was developed. The process is postulated to involve an intramolecular oxidative C(sp2)-C(sp 3) bond formation
Enaminones 9. Further studies on the anticonvulsant activity and potential type IV phosphodiesterase inhibitory activity of substituted vinylic benzamides
Anderson, Alan J.,Nicholson, Jesse M.,Bakare, Oladapo,Butcher, Ray J.,Wilson, Tiffany L.,Scott
, p. 997 - 1006 (2007/10/03)
Structure-activity relationship studies were employed to synthesize a series of 3- and 3,4-substituted benzamides from 3-amino-2-cyclohexenones. An improved method for the synthesis of benzamides from 3-amino-2-cyclohexenones is presented which provided s
Cul/N,N-dimethylglycine-catalyzed coupling of vinyl halides with amides or carbamates
Pan, Xianhua,Cai, Qian,Ma, Dawei
, p. 1809 - 1812 (2007/10/03)
Matrix presented. The Cul-catalyzed coupling reaction of vinyl halides with amides or carbamates proceeds well at room temperature to 80°C in dioxane to give enamides using N,N-dimethylglycine as the promoter and Cs 2CO3 as the base.
Synthesis, characterization and anticonvulsant activity of enaminones. Part 6: Synthesis of substituted vinylic benzamides as potential anticonvulsants
Foster, James E.,Nicholson, Jesse M.,Butcher, Raymond,Stables, James P.,Edafiogho, Ivan O.,Goodwin, Angela M.,Henson, Michael C.,Smith, Carlynn A.,Scott
, p. 2415 - 2425 (2007/10/03)
A comparison of enaminones from various unsubstituted and p-substituted benzamides to the analogous benzylamines has been undertaken with the aim of elucidating the essential structural parameters necessary for anticonvulsant activity. Initial studies on methyl 4-N-(benzylamino)-6-methyl-2-oxocyclohex- 3-en-1-oate, 3a, 3-N-(benzylamino)cyclohex-2-en-1-one, 3p, and 5,5-dimethyl- 3-N-(benzylamino)-cyclohex-2-en-1-one, 3r indicated that benzylamines possessed significant anti-maximal electroshock seizure (MES) activity. Evaluation of the analogous benzamides revealed significant differences in anticonvulsant activity, these differences were most probably related to the differences in their three-dimensional structures. (C) 1999 Elsevier Science Ltd.
