90290-04-3

Basic information

• Product Name: trans-N-benzyl-2,5-bis(ethoxycarbonyl)pyrrolidine
• CAS NO: 90290-04-3
• Molecular Weight: 305.374
• Mol File: 90290-04-3.mol

Chemical Properties

• CAS DataBase Reference: trans-N-benzyl-2,5-bis(ethoxycarbonyl)pyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: trans-N-benzyl-2,5-bis(ethoxycarbonyl)pyrrolidine(90290-04-3)
• EPA Substance Registry System: trans-N-benzyl-2,5-bis(ethoxycarbonyl)pyrrolidine(90290-04-3)

Safety Data

• Hazardous Substances Data: 90290-04-3(Hazardous Substances Data)

Upstream product

• 17740-40-8 diethyl meso-1-benzyl-2,5-pyrrolidinedicarboxylate 
• 52321-06-9 cis-1-benzylpyrrolidine-2,5-dicarboxylic acid diethyl ester 
• 869-10-3 diethyl 2,5-dibromoadipate 
• 100-46-9 benzylamine 

Downstream Products

• 90290-34-9 (R)-1-((2S,5S)-2,5-Bis-methoxymethoxymethyl-pyrrolidin-1-yl)-2-methyl-3-phenyl-propan-1-one 
• 90290-30-5 1-((2S,5S)-2,5-Bis-methoxymethoxymethyl-pyrrolidin-1-yl)-3-phenyl-propan-1-one 
• 93713-34-9 (2R,5R)-1-Benzyl-pyrrolidine-2,5-dicarboxylic acid; compound with 2-amino-1-(4-nitro-phenyl)-propane-1,3-diol 
• 136175-17-2 (2S,5S)-5-[(3S,5S)-1-Acetyl-5-(4-nitro-phenoxycarbonyl)-pyrrolidin-3-ylsulfanylmethyl]-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester 
• 136175-17-2 (2S,5S)-5-[(3S,5S)-1-Acetyl-5-(4-nitro-phenoxycarbonyl)-pyrrolidin-3-ylsulfanylmethyl]-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester 
• 136235-07-9 Racemic trans-1-(tert-Butoxycarbonyl)-2-(methoxycarbonyl)-5-<(tosyloxy)methyl>pyrrolidine 
• 120980-88-3 trans-1-(tert-Butoxycarboxyl)-2(S)-(methoxycarbonyl)-5(S)-<(tosyloxy)methyl>pyrrolidine 
• 118396-01-3 (-)-(2S,5S)-N-benzyl-trans-2,5-bis(methoxycarbonyl)pyrrolidine 
• 90290-05-4 (2S,5S)-2,5-bis(methoxymethyl)pyrrolidine 
• 52321-07-0 (2S,5S)-1-Benzylpyrrolidine-2,5-dicarboxylic acid 
• 93713-33-8 rac-trans-1-Benzyl-2,5-dicarboxypyrrolidine 
• 52321-06-9 cis-1-benzylpyrrolidine-2,5-dicarboxylic acid diethyl ester 

Relevant articles and documents

Synthesis of bridged bicyclic amino alcohols as compact modules for medicinal chemistry

The efficient synthetic routes of three bridged bicyclic amino alcohols were reported. It is conceivable that these compounds could be readily used as compact modules in medicinal chemistry to fine-tune physicochemical and pharmacokinetic properties, in order to eventually improve the overall quality of small molecule drug candidates.

Base-Catalysed Epimerization Behavior and Unusual Reactivity of N-Substituted Derivatives of 2,5-Dicarbalkoxypyrrolidine. Preparation of a Novel Mixed Carbamic Carbonic Anhydride by a 4-(Dimethylamino)pyridine-Catalyzed Acylation

The equilibration of cis-trans isomers of 1-substituted 2,5-dicarbalkoxypyrrolidine derivatives (1 = CH2Ph, H, CN, CO2R) results in nearly 1:1 mixtures, contrary to a literature report for 1-benzyl-2,5-dicarbalkoxypyrrolidine.Apparent conversion to the tr