52411-62-8Relevant academic research and scientific papers
Tandem aldol-allylation reactions: Double C-C bond formation using silicon-tethered dinucleophiles
Frost, Lisa M.,Smith, Julian D.,Berrisford, David J.
, p. 2183 - 2186 (1999)
A new tandem C-C bond forming process has been developed which utilises silicon-tethered dinucleophiles and acetals under Lewis acid conditions. The reaction incorporates a functionalised five carbon unit into both aromatic and aliphatic acetals, affording acyclic-β-alkoxyhomoallylic alcohols in good yields.
Ti-direct, powerful, stereoselective aldol-type additions of esters and thioesters to carbonyl compounds: Application to the synthesis and evaluation of lactone analogs of jasmone perfumes
Nagase, Ryohei,Matsumoto, Noriaki,Hosomi, Kohei,Higashi, Takahiro,Funakoshi, Syunsuke,Misaki, Tomonori,Tanabe, Yoo
, p. 151 - 159 (2008/03/28)
An efficient TiCl4-Et3N or Bu3N-promoted aldol-type addition of phenyl and thiophenyl esters or thioaryl esters with aldehydes and ketones was performed (total 46 examples). The present method is advantageous from atom-economical and cost-effective viewpoints; good to excellent yields, moderate to good syn-selectivity, substrate variations, reagent availability, and simple procedures. Utilizing the present reaction as the key step, an efficient short synthesis of three lactone [2(5H)-furanone] analogs of jasmine perfumes was performed. Among them, the lactone analog of cis-jasmone had a unique perfume property (tabac). The Royal Society of Chemistry.
Powerful stereoselective aldol-type additions of phenyl and phenylthio esters with aldehydes or ketones mediated by TiCl4/amine reagent
Tanabe,Matsumoto,Funakoshi,Manta
, p. 1959 - 1961 (2007/10/03)
An efficient TiCl4/amine-promoted aldol-type addition of phenyl and phenylthio esters with aldehydes or ketones has been performed. The present method includes a practical merit from the green chemical viewpoint with regard to yields, variations of substrates, availability of reagents, and simple operations.
