52443-97-7

Upstream product

• 7713-79-3 3-phenyl-5-isoxazolone 
• 104-55-2 3-phenyl-propenal 
• 1088-32-0 3-phenyl-4-(1-phenylmethylidene)-5-isoxazolone 
• 36298-61-0 3-phenyl-4-benzylideneisoxazol-5(4H)-one 
• 121-44-8 triethylamine 
• 1076-59-1 3-phenyl-4H-isoxazol-5-one 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 22155-13-1 6c-methoxy-3,4r-diphenyl-5,6-dihydro-4H-pyrano[3,2-d]isoxazole 
• 22155-13-1 6t-methoxy-3,4r-diphenyl-5,6-dihydro-4H-pyrano[3,2-d]isoxazole 
• 15166-58-2 6c-ethoxy-3,4r-diphenyl-5,6-dihydro-4H-pyrano[3,2-d]isoxazole 
• 15166-58-2 6t-ethoxy-3,4r-diphenyl-5,6-dihydro-4H-pyrano[3,2-d]isoxazole 
• 36221-11-1 4-(2-nitro-benzylidene)-3-phenyl-4H-isoxazol-5-one 

Downstream Products

• 120621-42-3 3-Phenyl-4-((Z)-3-phenyl-allyl)-4H-isoxazol-5-one 

Relevant academic research and scientific papers

Fast and efficient synthesis of 4-arylidene-3-phenylisoxazol-5-ones

A convenient and easy synthesis of 4-arylidene-3-phenylisoxazol-5-ones by the three-component reaction of hydroxylamine, ethyl benzoylacetate and aromatic aldehydes in the presence of DABCO in refluxing ethanol is reported.

4-Arylmethylisoxazol-5-one derivatives - Novel synthesis, structural studies, and supramolecular self-assembly through resonance-assisted hydrogen bonding

Arylmethylisoxazol-5-ones (3) were prepared by a new mild reductive procedure using tertiary amines containing a flexible N-CH-CH grouping. A concurrent process competed with the reduction, yielding fair quantities of chain-elongation products (4). The X-ray structures of two selected arylmethyl derivatives are reported and are shown to have the expected different tautomeric arrangements. The unusual features of the NH-tautomer (3e) were interpreted in terms of the RAHB (resonance-assisted hydrogen bond) model and its relative stability was investigated by ab initio and DFT calculations.