5246-58-2

Basic information

• Product Name: 2-[(p-aminophenyl)sulphonyl]ethanol
• Synonyms: 2-[(p-aminophenyl)sulphonyl]ethanol;-[(4-Aminophenyl)-sulfonyl]-ethanol;[(4-Aminophenyl)-sulfonyl]-ethanol;4-Aminophenyl-β-hydroxyethyl sulfone;AMINOSULPHONEB(P-BASEDERIVATIVES);2-[(4-Aminophenyl)-sulfonyl]-ethanol;2-(p-Aminophenylsulfonyl)ethanol;4-(2-Hydroxyethylsulfonyl)aniline
• CAS NO: 5246-58-2
• Molecular Formula: C₈H₁₁NO₃S
• Molecular Weight: 201.24284
• EINECS: 226-047-9
• Mol File: 5246-58-2.mol
• Article Data: 5

Chemical Properties

• Melting Point: 210-213 °C (decomp)
• Boiling Point: 469.2 °C at 760 mmHg
• Flash Point: 237.5 °C
• Appearance: /
• Density: 1.364 g/cm³
• Vapor Pressure: 1.32E-09mmHg at 25°C
• Refractive Index: 1.592
• PKA: 13.83±0.10(Predicted)
• CAS DataBase Reference: 2-[(p-aminophenyl)sulphonyl]ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(p-aminophenyl)sulphonyl]ethanol(5246-58-2)
• EPA Substance Registry System: 2-[(p-aminophenyl)sulphonyl]ethanol(5246-58-2)

Safety Data

• Hazardous Substances Data: 5246-58-2(Hazardous Substances Data)

Usage

General Description

2-[(p-aminophenyl)sulphonyl]ethanol, also known as APSE, is a chemical compound that belongs to the class of sulfonamides. It is commonly used as a reagent in organic synthesis and as an intermediate in the production of pharmaceuticals. APSE is a versatile compound with various applications in the pharmaceutical and chemical industries, including as a building block in the synthesis of other organic compounds, and as a key ingredient in the production of certain drugs and pesticides. Its structure consists of a sulphonamide group attached to a phenyl ring, which in turn is connected to an ethyl chain, making it a valuable and versatile chemical for a range of synthetic purposes. Additionally, it has been studied for its potential therapeutic applications, particularly in the field of anti-inflammatory and analgesic drugs.

InChI:InChI=1/C8H11NO3S/c9-7-1-3-8(4-2-7)13(11,12)6-5-10/h1-4,10H,5-6,9H2

Upstream product

• 21386-32-3 p-nitrophenyl-β-hydroxyethylsulfone 
• 100-00-5 4-chlorobenzonitrile 
• 1849-36-1 para-nitrobenzenethiol 
• 13287-76-8 2-(p-nitrophenylthio)ethanol 

Downstream Products

• 25781-90-2 1-amino-4-vinylsulphonylbenzene 
• 49545-85-9 2-(4-amino-3-bromo-benzenesulfonyl)-ethanol 
• 98491-05-5 2-(4-amino-3,5-dichloro-benzenesulfonyl)-ethanol 
• 108537-44-6 2-(4-amino-3,5-dibromo-benzenesulfonyl)-ethanol 
• 2494-89-5 2-(p-aminophenylsulfonyl)ethyl hydrogen sulfate 
• 128954-38-1 N-ethyl-4-(β-hydroxyethylsulfone)aniline 
• 1224162-19-9 2-{4-[4-((1R,2R)-2-Benzyloxy-1-methylpropoxy)-5-trifluoromethylpyrimidin-2-ylamino]benzene-sulphonyl}ethanol 

Relevant articles and documents

Preparing methods of p-aminophenyl-beta-hydroxyethylsulfonyl and p-minophenyl-beta-hydroxyethylsulfonyl sulphonate

The invention relates to preparing methods of p-aminophenyl-beta-hydroxyethylsulfonyl and p-minophenyl-beta-hydroxyethylsulfonyl sulphonate. The preparing methods both comprise the steps that p-aminophenyl-beta-hydroxyethylsulfonyl and hydrogen are used as raw materials, modified framework nickel is used as a hydrogen-adding catalyst, a catalytic hydrogenation reaction is conducted in a solvent toobtain reduction liquid, and modified framework nickel and the solvent in the reduction liquid are separated and removed to obtain p-minophenyl-beta-hydroxyethylsulfonyl sulphonate; according to modified framework nickel, nickel is used as a framework, and modified framework nickel is prepared from, by mass, 75-95 parts of Ni, 3-15 parts of Al and 2-10 parts of metal adjuvant; the metal adjuvantcomprises the combination of any one or at least two of Mo, Cu and Cr. The yield can reach 94% or above; preparation of p-minophenyl-beta-hydroxyethylsulfonyl sulphonate is a continuous production technology, the technology is simplified, the production efficiency is high, the quality is stable, the production cost is low, and the economic benefit and social benefit are obvious.

(R)-3-(N,N-DIMETHYLAMINO)PYRROLIDINE DERIVATIVES

(R)-3-(N,N-Dimethyiamino)pyrrolidine derivatives of formula (I), wherein the meaning for Cy1 is as disclosed in the description. These compounds are useful as JAK3 kinase inhibitors

Process for producing aminophenyl-β-hydroxyethylsulfone

A process for producing aminophenyl-β-hydroxyethylsulfone of the formula (I), STR1 which comprises the following steps: (1) condensing nitrohalobenzene with mercaptoethanol in the presence of an alkali hydroxide and at least one reaction medium selected from N-alkyl-substituted amides and sulfoxides to produce mononitrophenyl-β-hydroxyethylsulfide of the formula (II): STR2 (2) oxidizing the mononitrophenyl-β-hydroxyethylsulfide (II) to produce mononitrophenyl-β-hydroxyethylsulfone of the formula (III): STR3 and (3) reducing the mononitrophenyl-β-hydroxyethylsulfone to produce the aminophenyl-β-hydroxyethylsulfone of the formula (I). This compound is useful as an intermediate for aminophenyl-β-sulfatoethylsulfone represented by the following formula: STR4 which is an important intermediate for vinyl sulfone type reactive dyes largely used for dyeing cellulose fiber materials.