52464-51-4

Usage

General Description

2-(pentyloxy)aniline is a chemical compound with the molecular formula C12H17NO. It is an aniline derivative with a pentyl group attached to the oxygen atom. 2-(pentyloxy)aniline is commonly used as an intermediate in the synthesis of various organic compounds and pharmaceuticals. It has potential applications in the production of dyes, pigments, and polymers. Additionally, 2-(pentyloxy)aniline may also be used in research and development in the fields of organic chemistry and medicinal chemistry. It is important to handle this chemical with care and follow proper safety precautions due to its potential health hazards.

Upstream product

• 39645-91-5 1-nitro-2-(pentyloxy)benzene 
• 86255-27-8 silver(I) 2-nitrophenoxide 
• 110-53-2 1-Bromopentane 
• 614-80-2 2-(acetylamino)phenol 
• 95-55-6 2-amino-phenol 
• 55792-54-6 acetic acid-(2-pentyloxy-anilide) 
• 1624-53-9 2-(benzylideneamino)phenol 
• 88-75-5 2-hydroxynitrobenzene 
• 628-17-1 amyl iodide 
• 65347-86-6 (2-Pentyloxy-phenyl)-carbamic acid 2-morpholin-4-yl-ethyl ester 

Downstream Products

• 859934-94-4 (2-iodo-phenyl)-pentyl ether 
• 32223-65-7 2-n-Pentyloxyphenylisocyanat 
• 98771-63-2 6-Oxo-2-(2-pentyloxy-phenylamino)-1,6-dihydro-pyrimidine-5-carboxylic acid ethyl ester 
• 98772-15-7 6-Oxo-2-(2-pentyloxy-phenylamino)-1,6-dihydro-pyrimidine-5-carboxylic acid 

Relevant academic research and scientific papers

Determination of critical micellar concentration of homologous 2-alkoxyphenylcarbamoyloxyethyl-morpholinium chlorides

The critical micellar concentrations of selected alkyloxy homologues of local anesthetic 4-(2-[(2-alkoxyphenyl)carbamoyl]oxy ethyl)morpholin-4-ium chloride with nc = 2, 4, 5, 6, 7, 8, and 9 carbons in alkyloxy tail were determined by absorption spectroscopy in the UV–vis spectral region with the use of a pyrene probe. Within the homologous series of the studied amphiphilic compounds, the ln(cmc) was observed to be dependent linearly on the number of carbon atoms nc in the hydrophobic tail: ln(cmc) = 0.705–0.966 nc. The Gibbs free energy, necessary for the transfer of the methylene group of the alkoxy chain from the water phase into the inner part of the micelle at the temperature of 25?C and pH ≈ 4.5–5.0, was found to be ?2.39 kJ/mol. The experimentally determined cmc values showed good correlations with the predicted values of the bulkiness of the alkoxy tail expressed as the molar volume of substituent R, as well as with the surface tension of the compounds.

Dibasic derivatives of phenylcarbamic acid against mycobacterial strains: Old drugs and new tricks?

In order to provide a more detailed view on the structure–antimycobacterial activity relationship (SAR) of phenylcarbamic acid derivatives containing two centers of protonation,1-[2-[({[2-/3-(alkoxy)phenyl]amino}carbonyl)oxy]-3-(dipropylammonio)propyl]pyrrolidinium oxalates (1a–d)/dichlorides (1e–h) as wellas1-[2-[({[2-/3-(alkoxy)phenyl]amino}carbonyl)oxy]-3-(di-propylammonio)propyl]azepanium oxalates (1i–l)/dichlorides (1m–p; alkoxy = butoxy to heptyloxy) were physicochemically characterized by estimation of their surface tension (γ; Traube’s stalagmometric method), electronic features (log ε; UV/Vis spectrophotometry) and lipophilic properties (log kw; isocratic RP-HPLC) as well. The experimental log kw dataset was studied together with computational logarithms of partition coefficients (log P) generated by various methods based mainly on atomic or combined atomic and fragmental principles. Similarities and differences between the experimental and in silico lipophilicity descriptors were analyzed by unscaled principal component analysis (PCA). The in vitro activity of compounds 1a–p was inspected against Mycobacterium tuberculosis CNCTC My 331/88 (identical with H37Rv and ATCC 2794, respectively), M. tuberculosis H37Ra ATCC 25177, M. kansasii CNCTC My 235/80 (identical with ATCC 12478), the M. kansasii 6509/96 clinical isolate, M. kansasii DSM 44162, M. avium CNCTC My 330/80 (identical with ATCC 25291), M. smegmatis ATCC 700084 and M. marinum CAMP 5644, respectively. In vitro susceptibility of the mycobacteria to reference drugs isoniazid, ethambutol, ofloxacin or ciprofloxacin was tested as well. A very unique aspect of the research was that many compounds from the set 1a–p were highly efficient almost against all tested mycobacteria. The most promising derivatives showed MIC values varied from 1.9 μM to 8 μM, which were lower compared to those of used standards, especially if concerning ability to fight M. tuberculosis H37Ra ATCC 25177, M. kansasii DSM 44162 or M. avium CNCTC My 330/80. Current in vitro biological assays and systematic SAR studies based on PCA approach as well as fitting procedures, which were supported by relevant statistical descriptors, proved that the compounds 1a–p represented a very promising molecular framework for development of ‘non-traditional’ but effective antimycobacterial agents.

Investigations on the 4-quinolone-3-carboxylic acid motif. 4. Identification of new potent and selective ligands for the cannabinoid type 2 receptor with diverse substitution patterns and antihyperalgesic effects in mice

Experimental evidence suggests that selective CB2 receptor modulators may provide access to antihyperalgesic agents devoid of psychotropic effects. Taking advantage of previous findings on structure-activity/selectivity relationships for a class of 4-quin

Selective alkylation of aminophenols

O-or N-Alkylated derivatives of aminophenols are important synthetic intermediates in organic synthesis. A series of aminophenols were selectively alkylated on their hydroxyl group in good yields via benzaldehyde protection of the amino group, subsequent alkylation, and hydrolysis; or on their amino group via imination and following reduction. ARKAT USA, Inc.