5251-93-4

Usage

Uses

Used in Pharmaceutical Industry:
BENZADOX is used as an inhibitor for peptidylglycine α-hydroxylating monooxygenase (PHM) for its potential role in the development of new therapeutic strategies and treatments. Its ability to inhibit PHM can be beneficial in the research and development of drugs targeting specific enzyme-related conditions.
Used in Agricultural Industry:
BENZADOX is used as a pesticide for its ability to control and manage pests in the agricultural sector. Its effectiveness in inhibiting certain biological processes makes it a valuable tool in protecting crops and ensuring a healthy yield.
Used in Chemical Research:
BENZADOX, being a hippurate analog, is used as a research compound in the field of chemical research. Its unique properties and ability to inhibit PHM make it an interesting subject for further study and potential development of new chemical compounds and applications.

InChI:InChI=1S/C9H9NO4/c11-8(12)6-14-10-9(13)7-4-2-1-3-5-7/h1-5H,6H2,(H,10,13)(H,11,12)

Upstream product

• 495-18-1 Benzohydroxamic acid 
• 79-08-3 bromoacetic acid 
• 98-88-4 benzoyl chloride 
• 93-58-3 benzoic acid methyl ester 
• 645-88-5 aminooxyacetic acid 
• 90557-80-5 benzimidoylaminooxy-acetic acid 
• 79-11-8 chloroacetic acid 
• 2921-14-4 (aminooxy)acetic acid hemihydrochloride 

Downstream Products

• 645-88-5 aminooxyacetic acid 
• 15294-96-9 3-phenyl-[1,4,2]dioxazin-5-one 
• 614-44-8 benzoyloxyacetic acid 
• 65-85-0 benzoic acid 
• 20295-82-3 O-carboxymethylhydroxylamine hydrochloride 
• 1207113-81-2 C₁₅H₁₃ClN₂O₃ 

Relevant academic research and scientific papers

Design, synthesis and prostate cancer cell-based studies of analogs of the Rho/MKL1 transcriptional pathway inhibitor, CCG-1423

We recently identified bis(amide) CCG-1423 (1) as a novel inhibitor of RhoA/C-mediated gene transcription that is capable of inhibiting invasion of PC-3 prostate cancer cells in a Matrigel model of metastasis. An initial structure-activity relationship study focusing on bioisosteric replacement of the amides and conformational restriction identified two compounds, 4g and 8, with improved selectivity for inhibition of RhoA/C-mediated gene transcription and attenuated cytotoxicity relative to 1. Both compounds were also capable of inhibiting cell invasion with equal efficacy to 1 but with less attendant cytotoxicity.

Process for producing aminooxyacetic acid salts

A process for producing an aminooxyacetic acid salt comprises reacting benzhydroxamic acid of formula: STR1 (where R1 is a hydrogen atom, an alkyl group, an alkoxy group or a halogen atom) with a halogenoacetic acid of formula: (where X is an iodine, bromine or chlorine atom) in the presence of a metal hydroxide or a metal carbonate to form benzamidooxyacetic acid of formula (IV): STR2 and thereafter hydrolyzing the benzamidooxyacetic acid in the presence of a mineral acid to obtain an aminooxyacetic acid salt of formula:

5,6-Dihydro-1,2,4,6-thiatriazin-5-one-1,1-dioxides

5,6-Dihydro-1,2,4,6-thiatriazin-5-one-1,1-dioxides of the formula STR1 where R1 is hydrogen, a metal atom or an unsubstituted or substituted ammonium radical, R2 is a saturated or unsaturated straight-chain aliphatic radical of up to 10 carbon atoms, a cycloaliphatic radical or 3 to 7 carbon atoms, a branched saturated or unsaturated aliphatic radical of 3 to 10 carbon atoms, a halogen-, alkoxy- or alkylmercapto-substituted aliphatic radical of 2 to 10 carbon atoms tetrahydrofuryl substituted methyl, a cycloalkoxy-substituted aliphatic radical of 4 to 10 carbon atoms, unsubstituted or halogen-substituted benzyl or phenyl, halophenyl, or alkylphenyl of a total of up to 10 carbon atoms, R3 is hydrogen, a straight-chain aliphatic radical of up to 10 carbon atoms, a cycloaliphatic radical of 3 to 7 carbon atoms, a branched aliphatic radical of 3 to 10 carbon atoms, haloalkyl, or alkoxyalkyl of 2 to 10 carbon atoms and X is oxygen and may also be sulfur if R2 is unsubstituted or halogen-substituted benzyl, processes for their preparation, and herbicides containing the above compounds.