326-65-8

Basic information

• Product Name: 2-ACETAMIDE-5-FLUOROTOLUENE
• Synonyms: 2-ACETAMIDE-5-FLUOROTOLUENE;2-ACETAMIDO-5-FLUOROTOLUENE;4-FLUORO-2-METHYLACETANILIDE;N-(4-Fluoro-2-methylphenyl)acetamide;AcetaMide, N-(4-fluoro-2-Methylphenyl)-
• CAS NO: 326-65-8
• Molecular Formula: C₉H₁₀FNO
• Molecular Weight: 167.18
• Mol File: 326-65-8.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-ACETAMIDE-5-FLUOROTOLUENE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-ACETAMIDE-5-FLUOROTOLUENE(326-65-8)
• EPA Substance Registry System: 2-ACETAMIDE-5-FLUOROTOLUENE(326-65-8)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 326-65-8(Hazardous Substances Data)

Usage

General Description

2-Acetamide-5-fluorotoluene is a chemical compound with the molecular formula C9H10FNO. It is a white to yellow crystalline solid that is insoluble in water but soluble in organic solvents. 2-ACETAMIDE-5-FLUOROTOLUENE is primarily used as an intermediate in the production of pharmaceuticals and agrochemicals. It is also used as a building block for the synthesis of various organic compounds. 2-Acetamide-5-fluorotoluene is a potent skin irritant and should be handled with care in a well-ventilated area and with appropriate personal protective equipment. It has potential health hazards and exposure should be limited in occupational and industrial settings.

Upstream product

• 70786-65-1 N-ethanoyl-2-methylphenylhydroxyamine 
• 452-71-1 4-fluor-2-methylaniline 
• 108-24-7 acetic anhydride 
• 367-29-3 3-fluoro-6-methylaniline 

Downstream Products

• 332903-47-6 2-chloro-4-fluoro-6-methyl-aniline 
• 159020-73-2 N-(4-fluoro-2-methyl-6-nitrophenyl)acetamide 
• 147285-87-8 4-fluoro-2-methyl-6-nitrophenylamine 
• 1463053-91-9 2-bromo-5-fluoro-1-methyl-3-nitrobenzene 
• 1463053-93-1 2-bromo-5-fluoro-3-methylaniline 
• 452-71-1 4-fluor-2-methylaniline 
• 749920-54-5 2-chloro-6-fluoro-quinoline-3-carboxaldehyde 
• 101861-53-4 2-(methylcarbonylamino)-4-bromobenzoic acid 
• 394-27-4 2-acetamido-4-fluorobenzoic acid 
• 273401-26-6 N-(4-fluoro-2-methyl-5-nitrophenyl)acetamide 
• 446-08-2 2-amino-5-fluorobenzoic acid 
• 52548-63-7 5-fluoro-2-iodobenzoic acid 
• 56096-98-1 [2-(4-Chloro-phenylsulfanyl)-5-fluoro-phenyl]-acetic acid 
• 56096-96-9 [2-(4-Chloro-phenylsulfanyl)-5-fluoro-phenyl]-acetonitrile 

Relevant articles and documents

4 - Fluorine substituted aryl amine compound and synthesis method thereof

The invention discloses a synthesis method of 4 -fluorine substituted aryl amine compound, which comprises the following steps: 1) taking acyl-protected phenylhydroxylamine as a substrate, and generating 4 -fluorine substituted aniline compound under basic conditions by taking sulfonyl fluoride as a fluorine source in a polar solvent. 2) The deprotection is carried out under dilute acid conditions or Pd by catalytic hydrogenation to give the 4 - fluorine-substituted aryl amine compound. 4 - Fluorine substituted aniline compounds which are synthesized by the invention greatly increase the lipophilic property due to the introduction of fluorine atoms, and can be widely applied to preparation of fluorine-containing drugs and pesticide and dye intermediates. , The adopted raw materials are industrial products, are cheap and easily available, and are commercially available. 4 - Fluoroaryl aniline prepared by the method is high in yield, and the product with the purity 90% can be obtained in a yield of more than ≥ 99%. The method is simple to operate and low in cost, is very suitable for industrialization, and can be widely popularized and used.

POLYCYCLIC TLR7/8 ANTAGONISTS AND USE THEREOF IN THE TREATMENT OF IMMUNE DISORDERS

The present invention relates to compounds of Formula (I) and pharmaceutically acceptable compositions thereof, useful as toll-like receptor 7/8 (TLR7/8) antagonists. In Formula (I), Ring A is aryl or heteroaryl; Ring B is aryl or heteroary; and X is C(R4)2, O, NR4, S, S(R4), or S(R4)2.

Quinazolin-4(3H)-one derivatives as anticoccidial agents

Variously substituted trans-3-[3-(3-hydroxypiperid-2-yl)-2-oxopropyl]quinazolin-4-(3H)-ones, a method of controlling or preventing coccidiosis in poultry therewith, intermediates therefor, and a process for the preparation of certain intermediates therefor.