326-65-8

Usage

Uses

Used in Pharmaceutical Industry:
2-Acetamide-5-fluorotoluene is used as an intermediate for the synthesis of various pharmaceutical compounds. Its unique chemical structure allows it to be a key component in the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Acetamide-5-fluorotoluene serves as an intermediate in the production of agrochemicals. Its role in this industry is crucial for the development of effective pesticides and other agricultural chemicals that protect crops and enhance agricultural productivity.
Used as a Building Block in Organic Synthesis:
2-Acetamide-5-fluorotoluene is utilized as a building block for the synthesis of a wide range of organic compounds. Its versatile structure makes it a valuable component in organic chemistry, enabling the creation of various molecules with diverse applications across different industries.

Upstream product

• 367-29-3 3-fluoro-6-methylaniline 
• 452-71-1 4-fluor-2-methylaniline 
• 108-24-7 acetic anhydride 
• 70786-65-1 N-ethanoyl-2-methylphenylhydroxyamine 

Downstream Products

• 49579-56-8 2-acetamido-5-fluorobenzoic acid 
• 348-26-5 5-fluoro-1H-indazole 
• 332903-47-6 2-chloro-4-fluoro-6-methyl-aniline 
• 141071-11-6 1-Acetyl-5-fluorindazol 
• 56096-92-5 2-(4-Chlorphenylthio)-5-fluorbenzylalkohol 
• 56096-94-7 2-(4-Chlorphenylthio)-5-fluorbenzylchlorid 
• 56096-90-3 2-(4-Chlorphenylthio)-5-fluorbenzoesaeure 
• 56096-96-9 [2-(4-Chloro-phenylsulfanyl)-5-fluoro-phenyl]-acetonitrile 
• 56096-98-1 [2-(4-Chloro-phenylsulfanyl)-5-fluoro-phenyl]-acetic acid 
• 52548-63-7 5-fluoro-2-iodobenzoic acid 
• 446-08-2 2-amino-5-fluorobenzoic acid 
• 273401-26-6 N-(4-fluoro-2-methyl-5-nitrophenyl)acetamide 
• 101861-53-4 2-(methylcarbonylamino)-4-bromobenzoic acid 
• 394-27-4 2-acetamido-4-fluorobenzoic acid 

Relevant academic research and scientific papers

4 - Fluorine substituted aryl amine compound and synthesis method thereof

The invention discloses a synthesis method of 4 -fluorine substituted aryl amine compound, which comprises the following steps: 1) taking acyl-protected phenylhydroxylamine as a substrate, and generating 4 -fluorine substituted aniline compound under basic conditions by taking sulfonyl fluoride as a fluorine source in a polar solvent. 2) The deprotection is carried out under dilute acid conditions or Pd by catalytic hydrogenation to give the 4 - fluorine-substituted aryl amine compound. 4 - Fluorine substituted aniline compounds which are synthesized by the invention greatly increase the lipophilic property due to the introduction of fluorine atoms, and can be widely applied to preparation of fluorine-containing drugs and pesticide and dye intermediates. , The adopted raw materials are industrial products, are cheap and easily available, and are commercially available. 4 - Fluoroaryl aniline prepared by the method is high in yield, and the product with the purity 90% can be obtained in a yield of more than ≥ 99%. The method is simple to operate and low in cost, is very suitable for industrialization, and can be widely popularized and used.

Synthesis of indenoquinolinone through aryne-mediated Pd(II)-catalysed remote C–H activation

Abstract: [Figure not available: see fulltext.]Indenoquinolinones have been synthesized from 2-haloquinoline-3-carbaldehyde through Pd-mediated simultaneous C–H (aldehyde) and C–X bond activation. DFT studies were performed to investigate the mechanistic pathway, and in situ UV–Vis studies indicate the presence of Pd(II) intermediate species. Aryne ligated Pd complex is actual intermediate in these reactions. Ligation of reactive aryne to Pd reduces probability of side reactions. Graphic abstract: [Figure not available: see fulltext.]

POLYCYCLIC TLR7/8 ANTAGONISTS AND USE THEREOF IN THE TREATMENT OF IMMUNE DISORDERS

The present invention relates to compounds of Formula (I) and pharmaceutically acceptable compositions thereof, useful as toll-like receptor 7/8 (TLR7/8) antagonists. In Formula (I), Ring A is aryl or heteroaryl; Ring B is aryl or heteroary; and X is C(R4)2, O, NR4, S, S(R4), or S(R4)2.

CINNOLINE DERIVATIVES AS AS BTK INHIBITORS

Disclosed are compounds of Formula 1, and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R5 are defined in the specification. The compounds are inhibitors of Bruton's tyrosine

Quinazolin-4(3H)-one derivatives as anticoccidial agents

Variously substituted trans-3-[3-(3-hydroxypiperid-2-yl)-2-oxopropyl]quinazolin-4-(3H)-ones, a method of controlling or preventing coccidiosis in poultry therewith, intermediates therefor, and a process for the preparation of certain intermediates therefor.