5255-71-0

Usage

Uses

Used in Pharmaceutical Industry:
2-(METHYLPHENYL) CARBAMIC ACID ETHYL ESTER is used as an intermediate in the production of pharmaceuticals for its role in the synthesis of various pharmaceutical drugs. It contributes to the development of new medications by serving as a key component in their chemical structures.
Used in Agrochemical Industry:
In the agrochemical sector, 2-(METHYLPHENYL) CARBAMIC ACID ETHYL ESTER is used as an intermediate for the synthesis of pesticides and herbicides. Its involvement in the creation of these compounds helps to enhance crop protection and contribute to more effective agricultural practices.
Used in Organic Compounds Synthesis:
2-(METHYLPHENYL) CARBAMIC ACID ETHYL ESTER is also utilized as an intermediate in the synthesis of other organic compounds, highlighting its versatility in various chemical reactions and its importance in the broader field of organic chemistry.

InChI:InChI=1/C10H13NO2/c1-3-13-10(12)11-9-7-5-4-6-8(9)2/h4-7H,3H2,1-2H3,(H,11,12)

Upstream product

• 64-17-5 ethanol 
• 16080-08-3 (2-methylphenyl)carbonimidic dichloride 
• 541-41-3 chloroformic acid ethyl ester 
• 95-53-4 o-toluidine 
• 60-29-7 diethyl ether 
• 100-61-8 N-methylaniline 
• 817-87-8 ethyl azidocarbonate 
• 108-88-3 toluene 
• 71-43-2 benzene 
• 5408-04-8 ethyl 2-hydroxyimino-3-oxobutanoate 
• 1202047-19-5 1-tert-butyl-1-isopropyl-3-phenylurea 
• 74-88-4 methyl iodide 
• 636-21-5 o-toluidine hydrochloride 
• 614-69-7 2-tolyl isothiocyanate 

Downstream Products

• 614-68-6 2-tolyl isocyanate 
• 13140-49-3 N-(2-methylphenyl)-N'-phenylurea 
• 35600-65-8 Chloromethyl-o-tolyl-carbamic acid ethyl ester 
• 617-07-2 N,N'-bis(2-methylphenyl)urea 
• 128886-46-4 ((Z)-4-Hydroxy-but-2-enyl)-o-tolyl-carbamic acid ethyl ester 
• 128910-60-1 ((E)-4-Hydroxy-but-2-enyl)-o-tolyl-carbamic acid ethyl ester 
• 128886-62-4 (R)-5-((R)-1,2-Dihydroxy-ethyl)-3-o-tolyl-oxazolidin-2-one 
• 128886-62-4 (R)-5-((S)-1,2-Dihydroxy-ethyl)-3-o-tolyl-oxazolidin-2-one 
• 128886-52-2 ((2S,3S)-3-Hydroxymethyl-oxiranylmethyl)-o-tolyl-carbamic acid ethyl ester 
• 128886-52-2 ((2S,3R)-3-Hydroxymethyl-oxiranylmethyl)-o-tolyl-carbamic acid ethyl ester 
• 15940-63-3 4-(2-methylphenyl)semicarbazide 
• 1356965-17-7 2-[(1E)-1-(1,3-benzodioxol-5-yl)-4,4-dimethylpent-1-en-3-ylidene]-N-(2-methylphenyl)hydrazinecarboxamide 
• 1356965-25-7 (5RS)-5-(benzo[d][1,3]dioxol-5-yl)-3-tert-butyl-N-(2-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carboxamide 

Relevant academic research and scientific papers

An efficient one-pot synthesis of: N, N ′-disubstituted ureas and carbamates from N -acylbenzotriazoles

A facile and high-yielding one-pot synthesis of carbamates and N,N′-disubstituted symmetrical ureas from N-acylbenzotriazoles has been devised. It is believed that, the intermediate acyl-azide undergo Curtius rearrangement and in different solvents gives different products i.e. carbamates in alcohols and N,N′-disubstituted symmetrical urea in THF.

Design and synthesis of novel stiripentol analogues as potential anticonvulsants

A series of stiripentol (STP) analogues namely, 2-[(1E)-1-(1,3-benzodioxol- 5-yl)-4,4-dimethylpent-1-en-3-ylidene]-N-(aryl/H)hydrazinecarboxamides 7a-h, (±)-(5RS)-N-(aryl/H)-(1,3-benzodioxol-5-yl)-3-tert-butyl-4, 5-dihydro-1H-pyrazole-1-carboxamides (±)-8a-h, and (±)-[(5RS)-(1, 3-benzodioxol-5-yl)-3-tert-butyl-4,5-dihydro-1H-pyrazol-1-yl](aryl)methanones (±)-13a-f was synthesized by adopting appropriate synthetic routes and was pharmacologically evaluated in the preliminary anticonvulsant screens. The selected bioactive new chemical entities were subjected to ED50 determination and neurotoxicity evaluation. The most active congeners are 7h in MES screen and (±)-13b in scPTZ screen which displayed ED50 values of 87 and 110 mg/kg, respectively, as compared to that of STP (ED 50 = 277.7 and 115 mg/kg in MES and scPTZ, respectively).

Facile double-lithiation of a transient urea: Vicarious ortho -metalation of aniline derivatives

A convenient one-pot method for the conversion of phenylisocyanate into ortho-functionalized aniline derivatives has been developed. The reaction proceeds via the selective ortho-metalation of a transient labile urea, which can be considered as a synthetic equivalent of 2-lithio-phenylisocyanate, a highly improbable intermediate.

Unexpected Reaction of Oximinoacetoacetate with Amines: A Novel Synthesis of Carbamates

The synthesis of alkyl carbamates by a solvent-free reaction of oximinoacetoacetate and amine at 130C is reported. A preliminary mechanism to this unexpected reaction is also given.

Pyrazolinols

The use of pyrazolinols formula (I) in which A, Q, R1, R2, R3, R4 and R5 are as defined in the description for controlling pests, novel pyrazolinols and a plurality of processes for preparing these co

PYRAZOLINOLS USED AS PESTICIDES

The invention relates to the use of pyrazolinols of formula (I), in which A, Q, R1, R2, R3, R4 and R5 are defined as cited in the description, for controlling pests. The invention also relates to nove

Ultrasound promoted 'one pot' conversion of nitrocompounds to carbamates

An efficient ultrasound promoted novel direct conversion of nitro compounds to N-(tert-butoxycarbonyl) amines and N-(ethoxycarbonylamines) is achieved using Sn-NH4Cl for the first time.

The Biodegradation of Low-molecular-weight Urethane Compounds by a Strain of Exophiala jeanselmei

To further analyze the biodegradation of polyurethane polymers, we investigated the biodegradation of low-molecular-weight N-tolylcarbamate model compounds with structures closely resembling the urethane linkages found in polyurethanes based on tolylene-diisocyanate (TDT). Soil microflora were screened for microorganisms that were able to utilize toluene-2,4-dicarbamic acid, diethyl ester (compound 1) as the sole source of carbon, and the soil fungus Exophiala jeanselmei strain REN-11A was selected as the most effective strain. Several N-tolylcarbamate compounds were used, and it was found that REN-11A was able to degrade compound 1, as well as the related compound toluene-2,6-dicarbamic acid, diethyl ester, very efficiently. Further investigation showed that compound 1 was biodegraded to tolylene-2,4-diamine via the aromatic amine intermediates carbamic acid, (3-amino-4-methylphenyl)-, ethyl ester and carbamic acid, (5-amino-2-methylphenyl)-, ethyl ester.

Process for the preparation of urethanes

A process for the preparation of urethanes. Urethanes having the general formula R1 (NHCOOR2)n are reacted with an alcohol at a temperature of 120° to 400° C. in amounts such that, for every mol of the urethane, at least o

Electrophilic Aromatic N-Substitution by Ethoxycarbonylnitrenium Ion generated from Ethyl Azidoformate in the Presence of Trifluoroacetic Acid

Thermal reactions of ethyl azidoformate with aromatic compounds in the presence of trifluoroacetic acid (TFA) gave ethyl N-arylcarbamates.Toluene, nitrobenzene, or naphthalene was selectively attacked on the ortho- and para-positions, on the ortho- and meta-positions, or in the 1- and 2-positions, respectively.The yields were ca. twice as high as those for thermolysis ( a nitrene-azepine route) in the absence of TFA with the subsequent addition of TFA at room temperature.The positional selectivities for toluene and naphthalene were lower for the former thermolysis than for the latter.The reactivity of cyclohexane or toluene relative to benzene was greater in the latter thermolysis than the former.A Hammett plot with ρ - 1.7 was obtained for the formation of ethyl N-arylcarbamates in the former thermolysis in TFA-nitrobenzene (8:2 v/v); the value was more negative than that (-1.32) for the disappearance of substituted benzenes in the reaction with ethoxycarbonylnitrene.The results suggest that the thermolysis in the presence of TFA involves an electrophilic aromatic N-substitution by ethoxycarbonylnitrenium ion.