525585-56-2

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 32044-22-7 (R,R)-1,2-diaminocyclohexane tartrate 
• 32044-22-7 (1R,2R)-1,2-diaminocyclohexane tartrate 
• 20439-47-8 (1R,2R)-1,2-diaminocyclohexane 

Downstream Products

• 757190-59-3 (1R,2R)-N,N’-bis(4-methoxybenzyl)cyclohexane-1,2-diamine 
• 1217463-44-9 (R,R)-N-(2-{[2,2-bis(3,5-dimethylphenyl)acetyl]hydroxyamino}cyclohexyl)-2,2-bis(3,5-dimethylphenyl)-N-hydroxyacetamide 
• 860036-29-9 (R,R)-N-hydroxy-N-{2-[hydroxy-(3,3,3-triphenylpropionyl)amino]cyclohexyl}-3,3,3-triphenylpropionamide 
• 860036-16-4 (R,R)-N-[2-(diphenylacetylhydroxyamino)cyclohexyl]-N-hydroxy-2,2-diphenylacetamide 
• 860036-40-4 (R,R)-O,O'-bis(triethylsilyl)cyclohexyl-1,2-dihydroxylamine 
• 860036-37-9 C₂₂H₂₆N₂O₄ 

Relevant academic research and scientific papers

Chiral relay in NHC-mediated asymmetric β-lactam synthesis I; substituent effects in NHCs derived from (1R,2R)-cyclohexane-1,2-diamine

The synthesis of a range of C2-symmetric imidazolinium salts from (1R,2R)-cyclohexane-1,2-diamine, and an evaluation of the reactivity and asymmetric induction of the derived NHCs as catalysts for the asymmetric synthesis of β-lactams, is reported. In this series, optimal enantioselectivity (up to 70% ee) is observed using N-benzyl or N-1-naphthylmethyl-substituted NHCs, consistent with a chiral relay effect operating to dictate the stereochemical outcome of this reaction.

Enantioselective epoxidation of allylic alcohols by a chiral complex of vanadium: An effective controller system and a rational mechanistic model

(Chemical Equation Presented) Bishydroxamic acid derivatives are used as ligands for a vanadium catalyst in the preparation of epoxy alcohols (see scheme). The methodology uses aqueous tert-butyl hydroperoxide (TBHP) as an achiral oxidant, low catalyst loading, low reaction temperatures (0°C to room temperature), and simple workup procedures. The reaction is applied to the kinetic resolution of a secondary allylic alcohol and the preparation of small epoxy alcohols. R1, R2, R3: alkyl, aryl, H.

One catalyst for two distinct reactions: Sequential asymmetric hetero Diels-Alder reaction and diethylzinc addition

This paper describes the successful development of a series of chiral zinc catalysts containing (R)-3,3′-Br2-BINOL ligand and various diimine activators for enantioselective HDA reaction of Danishefsky's diene with aldehydes through a combinato

Catalytic asymmetric epoxidation

The present invention relates to the synthesis of chiral epoxides via a catalytic asymmetric oxidation of olefins. Additionally, the methodology provides a method of asymmetrically oxidizing sulfides and phosphines. This asymmetric oxidation employs a catalyst system composed of a metal and a chiral bishydroxamic acid ligand, which, in the presence of a stoichiometric oxidation reagent, serves to asymmetrically oxidize a variety of substrates.

An easy and clean synthesis of chiral 3,4-diaryl-2,5-diazabicyclo[4.4.0]decanes by reductive intramolecular coupling of chiral diimines

A clean and efficient reductive intramolecular coupling of diimines prepared from (1R,2R)-cyclohexanediamine gave chiral 2,3-diarylpiperazines.