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52580-57-1

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52580-57-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 52580-57-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,2,5,8 and 0 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 52580-57:
(7*5)+(6*2)+(5*5)+(4*8)+(3*0)+(2*5)+(1*7)=121
121 % 10 = 1
So 52580-57-1 is a valid CAS Registry Number.

52580-57-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name ethyl 2-benzamido-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:52580-57-1 SDS

52580-57-1Relevant articles and documents

Preparation method and application of tetrahydrobenzothiophene compound and pharmaceutical composition

-

, (2021/10/16)

The invention belongs to the field of medicines, and particularly relates to a tetrahydrobenzothiophene compound as well as a pharmaceutical composition and a preparation method and application thereof. The tetrahydrobenzothiophene compound is a compound I as shown I. In-flight R1 And R2 The C1 -4 is a saturated/unsaturated hydrocarbon group. - OCH3 , OCH2 CH3 Phenyl, substituted phenyl, NO2 One - COR of - OH - F, Cl - Br. I - H R1 AND R2 Or different. R3 It is-F. - Cl, Br, I, OH, Amino, C1 -4 saturated/unsaturated hydrocarbon group, OCH3 , OCH2 CH3 , H, Wherein one of them is, n ≥ 5, n Being an integer. The compound effectively inhibits salmonella by inhibiting the synthesis of ATP-dependent transporter in the lipopolysaccharide synthesis pathway. Aeruginosa, escherichia coli and staphylococcus aureus.

In vitro and in vivo evaluation of the antimalarial MMV665831 and structural analogs

Carlier, Paul R.,Ding, Sha,Fike, Katherine R.,Klemba, Michael

, (2020/07/03)

Antimalarial candidates possessing novel mechanisms of action are needed to control drug resistant Plasmodium falciparum. We were drawn to Malaria Box compound 1 (MMV665831) by virtue of its excellent in vitro potency, and twelve analogs were prepared to probe its structure–activity relationship. Modulation of the diethyl amino group was fruitful, producing compound 25, which was twice as potent as 1 against cultured parasites. Efforts were made to modify the phenolic Mannich base functionality of 1, to prevent formation of a reactive quinone methide. Homologated analog 28 had reduced potency relative to 1, but still inhibited growth with EC50 ≤ 200 nM. Thus, the antimalarial activity of 1 does not derive from quinone methide formation. Chemical stability studies on dimethyl analog 2 showed remarkable hydrolytic stability of both the phenolic Mannich base and ethyl ester moieties, and 1 was evaluated for in vivo efficacy in P. berghei-infected mice (40 mg/kg, oral). Unfortunately, no reduction in parasitemia was seen relative to control. These results are discussed in the context of measured plasma and hepatocyte stabilities, with reference to structurally-related, orally-efficacious antimalarials.

4,5,6,7-tetrahydrobenzothiophene compound application

-

Paragraph 0012, (2019/10/29)

The invention provides an application of a 4,5,6,7-tetrahydrobenzothiophene compound, in particular to an application of a compound with a structure in a formula (I) in preparing a beta-N-acetylhexosaminidase OfHex1 inhibitor. The invention provides that the compound with the structure in the formula (I) has a better inhibiting effect on the beta-N-acetylhexosaminidase OfHex1, can be used for pestcontrol, and has easily available raw materials and less synthesis difficulty, and can be used for industrial development.

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