13784-17-3Relevant academic research and scientific papers
Purine Studies. Part 24. Preparation of 1,6- and 7,8-Dihydro-derivatives of 8-Trifluoromethylpurines by Reduction
Albert, Adrien
, p. 2974 - 2977 (1981)
8-Trifluoromethylpurine (1a) was converted by catalytic hydrogenation entirely to the 1,6-dihydro-derivative (3a), whereas 9-methyl-8-trifluoromethylpurine (1b) produced a 2:1 mixture of the 1,6- (3b) and 7,8- (5) dihydroderivatives.The new hydrogenated purines are characterised by unusual stability.Physical properties are discussed and compared with those of analogues from several other heterocyclic series.
NOVEL CEPHALOSPORIN DERIVATIVE AND PHARMACEUTICAL COMPOSITION THEREOF
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Paragraph 0152, (2014/03/25)
The present invention relates to novel cephalosporin derivatives represented by Chemical Formula 1. Wherein, X, Y, L, R1, and R2 are as same as defined in the description of the invention. The present invention also relates to pharmaceutical antibiotic compositions comprising a novel celphalosporin derivative represented by Chemical Formula 1, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof as an effective ingredient. According to the present invention, novel cephalosporin derivatives, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof as an effective ingredient for the broad spectrum of antibiotic resistant, low toxicity, particularly in Gram-negative bacteria, which can be useful with strong antimicrobial activity.
