23126-82-1 Usage
Description
N4-METHYL-6-CHLORO-5-NITROPYRIMIDIN-4-AMINE, a chemical compound with the molecular formula C6H6ClN5O2, is a nitro-substituted pyrimidine derivative characterized by the presence of a nitro group at the 5-position and methyl and chloro groups at the 4 and 6 positions, respectively. It is a promising intermediate in the synthesis of various organic compounds, particularly in the pharmaceutical and agrochemical industries, and holds potential for applications in medicinal chemistry and biological research.
Uses
Used in Pharmaceutical Industry:
N4-METHYL-6-CHLORO-5-NITROPYRIMIDIN-4-AMINE is used as a chemical intermediate for the synthesis of pharmaceuticals, contributing to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
N4-METHYL-6-CHLORO-5-NITROPYRIMIDIN-4-AMINE is used as a chemical intermediate in the production of agrochemicals, such as pesticides and herbicides, to enhance crop protection and yield.
Used in Medicinal Chemistry:
N4-METHYL-6-CHLORO-5-NITROPYRIMIDIN-4-AMINE is utilized as a building block in the design and synthesis of novel compounds with potential medicinal properties, facilitating advancements in drug discovery and development.
Used in Biological Research:
N4-METHYL-6-CHLORO-5-NITROPYRIMIDIN-4-AMINE serves as a valuable compound in biological research, aiding in the study of various biological processes and the development of new therapeutic strategies.
Safety Precautions:
Due to its potentially hazardous nature, N4-METHYL-6-CHLORO-5-NITROPYRIMIDIN-4-AMINE should be handled with caution. It is essential to follow proper safety protocols and regulations for its use and storage to minimize risks and ensure the safety of individuals and the environment.
Check Digit Verification of cas no
The CAS Registry Mumber 23126-82-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,3,1,2 and 6 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 23126-82:
(7*2)+(6*3)+(5*1)+(4*2)+(3*6)+(2*8)+(1*2)=81
81 % 10 = 1
So 23126-82-1 is a valid CAS Registry Number.
23126-82-1Relevant articles and documents
Palladium-catalyzed amination of chloro-substituted 5-nitropyrimidines with amines
Liu, Meng-Meng,Mei, Qiong,Zhang, Yi-Xiao,Bai, Peng,Guo, Xiang-Hai
, p. 583 - 587 (2017/06/19)
A concise and efficient approach was developed for the synthesis of mono-substituted and di-substituted pyrimidines products via palladium-catalyzed amination of chloro-substituted 5-nitropyrimidines and amines. This synthetic methodology can produce vari
Novel 8-arylated purines as inhibitors of glycogen synthase kinase
Ibrahim, Nada,Mouawad, Liliane,Legraverend, Michel
scheme or table, p. 3389 - 3393 (2010/08/06)
A series of 8-arylated purine derivatives bearing either an aniline or an alkyl amide at position 6 were found to inhibit glycogen synthase kinase-3,with good selectivity over ten kinases. Molecular modeling studies indicated that the most active compounds (8a and 8e),adopt a planar conformation,close to the shape of AMPPNP in the crystal structure of GSK-3. These compounds are stabilized by hydrophobic contacts between the 8-aromatic group and the protein adenine pocket and by electrostatic contacts.
Purines, Pyrimidines, and Imidazoles. Part 61. Reaction of 6-Alkylamino-4-chloro-5-nitropyrimidines with Diethyl Malonate, Ethyl Cyanoacetate, and Ethyl Acetoacetate and some derived Pyrrolopyrimidines related to the Cytokinins
Gregson, Stephen,Shaw, Gordon
, p. 187 - 190 (2007/10/02)
Reaction of 4-chloro-6-methylamino-5-nitropyrimidine (3d) with diethyl malonate and sodium hydroxide afforded diethyl 6-methylamino-5-nitropyrimidin-4-ylmalonate which was reduced to diethyl 5-amino-6-methylaminopyrimidin-4-ylmalonate and this, with sodiu
