5269-38-5Relevant academic research and scientific papers
PROCESSES FOR PREPARING FUNCTIONALIZED CYCLOOCTENES
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Page/Page column 52-53, (2020/05/19)
The present disclosure relates to processes for preparing functionalized cyclooctenes and the synthetic intermediates prepared thereby.
Isostearyl Mixed Anhydrides for the Preparation of N-Methylated Peptides Using C-Terminally Unprotected N-Methylamino Acids
Cary, Douglas R.,Handa, Michiharu,Kobayashi, Yutaka,Kurasaki, Haruaki,Masuya, Keiichi,Matsuda, Ayumu,Matsumoto, Masatoshi,Morimoto, Koki,Nagaya, Akihiro,Nishizawa, Naoki,Taguri, Tomonori,Takeuchi, Hisayuki
supporting information, p. 8039 - 8043 (2020/11/02)
Sustainable and efficient manufacturing methods for N-methylated peptides remain underexplored despite growing interest in therapeutic N-methylated peptides within the pharmaceutical industry. A methodology for the coupling of C-terminally unprotected N-methylamino acids mediated by an isostearic acid halide (ISTAX) and silylating reagent has been developed. This approach allows for the coupling of a wide variety of amino acids and peptides in high yields under mild conditions without the need for a C-terminal deprotection step in the process of C-terminal elongation. These advantages make this a useful synthetic method for the production of peptide therapeutics and diagnostics containing N-methylamino acids.
Efficient "One-Pot" Synthesis of N-Trityl Amino Acids
Barlos, Kleomenis,Papaioannou, Dionysios,Theodoropoulos, Dimitrios
, p. 1324 - 1326 (2007/10/02)
A sequential procedure has been developed whereby neutral amino acids 1 were tritylated via their corresponding trimethylsilyl esters 2 to afford, after mild hydrolysis, N-trityl amino acids 3 in high yields and purity.Hydroxy amino acids 4 were preferent
