52707-91-2

Basic information

• Product Name: 1,2-Benzisothiazol-3(2H)-one, 2-(4-chlorobenzoyl)-, 1,1-dioxide
• CAS NO: 52707-91-2
• Molecular Formula: C14H8ClNO4S
• Molecular Weight: 321.741
• Mol File: 52707-91-2.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 1,2-Benzisothiazol-3(2H)-one, 2-(4-chlorobenzoyl)-, 1,1-dioxide(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Benzisothiazol-3(2H)-one, 2-(4-chlorobenzoyl)-, 1,1-dioxide(52707-91-2)
• EPA Substance Registry System: 1,2-Benzisothiazol-3(2H)-one, 2-(4-chlorobenzoyl)-, 1,1-dioxide(52707-91-2)

Safety Data

• Hazardous Substances Data: 52707-91-2(Hazardous Substances Data)

Upstream product

• 122-01-0 4-chloro-benzoyl chloride 
• 81-07-2 saccharin 
• 74-11-3 para-chlorobenzoic acid 
• 13947-20-1 N-(hydroxymethyl)saccharin 

Downstream Products

• 27942-64-9 n-butyl 4-chlorobenzoate 
• 104-88-1 4-chlorobenzaldehyde 
• 3277-80-3 (4-chlorophenyl)(cyclohexyl)methanone 
• 1517-46-0 4-chloro-N-methyl-N-phenyl-benzamide 
• 1310708-95-2 2-(4-chlorophenyl)-1-(pyrimidin-2-yl)-1H-indole 
• 1039045-16-3 10-(4-chlorophenyl)-7,8-benzoquinoline 
• 134-85-0 4-chlorobenzophenone 
• 42175-12-2 butyl (E)-4-chlorocinnamate 
• 16616-42-5 p-chlorobenzoylphenylacetylene 

Relevant articles and documents

A Strategy for Accessing Aldehydes via Palladium-Catalyzed C?O/C?N Bond Cleavage in the Presence of Hydrosilanes

We report the catalytic reduction of both active esters and amides by selective C(acyl)?X (X=O, N) cleavage to access aldehyde functionality via a palladium-catalyzed strategy. Reactions are promoted by hydrosilanes as reducing reagents with good to excellent yields and with excellent chemoselectivity for C(acyl)?N and C(acyl)?O bond cleavage. Carboxylic acid C(acyl)?O bonds are activated by 2-chloro-4,6-dimethoxy-1,3,5-triazine (CDMT) to form triazine ester intermediates, which further react with hydrosilanes to yield aldehydes in one-pot two-step procedures. We demonstrate that C(acyl)?O cleavage/formylation offers higher yields and broader substrate scopes compared with C(acyl)?N cleavage under the same reaction conditions.

Nickel-Mediated Photoreductive Cross Coupling of Carboxylic Acid Derivatives for Ketone Synthesis**

A simple visible light photochemical, nickel-catalyzed synthesis of ketones from carboxylic acid-derived precursors is presented. Hantzsch ester (HE) functions as a cheap, green and strong photoreductant to facilitate radical generation and also engages in the Ni-catalytic cycle to restore the reactive species. With this dual role, HE allows for the coupling of a large variety of radicals (1°,2°, benzylic, α-oxy & α-amino) with aroyl and alkanoyl moieties, a new feature in reactions of this type. With both precursors deriving from abundant carboxylic acids, this protocol is a welcome addition to the organic chemistry toolbox. The reaction proceeds under mild conditions without the need for toxic metal reagents or bases and shows a wide scope, including pharmaceuticals and complex molecular architectures.

A Straightforward Conversion of Activated Amides and Haloalkanes into Esters under Transition-Metal-Free Cs 2 CO 3 /DMAP Conditions

The esterification of activated amides, N -acylsaccharins, under transition-metal-free conditions with good functional group tolerance has been developed, resulting in C-N cleavage leading to efficient synthesis of a variety of esters in moderate to good yields. This work demonstrates that esterification may proceed by using simple N -acylsaccharins, haloalkanes, and Cs 2 CO 3 as oxygen source.