5279-51-6

Basic information

• Product Name: 4'-METHOXY-N-METHYLFORMANILIDE
• Synonyms: 4'-METHOXY-N-METHYLFORMANILIDE;N-(4-METHOXYPHENYL)-N-METHYLFORMAMIDE;4'-Methoxy-N-methylformanilide
• CAS NO: 5279-51-6
• Molecular Formula: C₉H₁₁NO₂
• Molecular Weight: 165.18914
• Mol File: 5279-51-6.mol
• Article Data: 73

Chemical Properties

• Melting Point: 26 °C
• Boiling Point: 309.5°C at 760 mmHg
• Flash Point: 26 °C
• Appearance: /
• Density: 1.11g/cm³
• Vapor Pressure: 0.000635mmHg at 25°C
• Refractive Index: 1.55
• PKA: 1.25±0.50(Predicted)
• CAS DataBase Reference: 4'-METHOXY-N-METHYLFORMANILIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-METHOXY-N-METHYLFORMANILIDE(5279-51-6)
• EPA Substance Registry System: 4'-METHOXY-N-METHYLFORMANILIDE(5279-51-6)

Safety Data

• Hazardous Substances Data: 5279-51-6(Hazardous Substances Data)

Usage

General Description

4’-Methoxy-N-methylformanilide, also known as monomethyloxyaniline, is an organic chemical compound belonging to the class of anilides. Its molecular formula is C9H11NO2, and it is a white crystalline solid with a molecular weight of 165.19 g/mol. 4'-METHOXY-N-METHYLFORMANILIDE is commonly used as an intermediate in the synthesis of various pharmaceuticals and dyes. It is also used as a raw material in the production of other organic chemicals and as a reagent in organic synthesis. In addition, 4’-methoxy-N-methylformanilide has been found to exhibit antimicrobial and antifungal properties, making it potentially useful in the development of new antimicrobial agents.

InChI:InChI=1/C9H11NO2/c1-10(7-11)8-3-5-9(12-2)6-4-8/h3-7H,1-2H3

Upstream product

• 64-18-6 formic acid 
• 5961-59-1 N-methyl-N-(4-methoxyphenyl)amine 
• 613-90-1 benzoyl cyanide 
• 701-56-4 4-methoxy-N,N-dimethylanilne 
• 123-39-7 N-Methylformamide 
• 696-62-8 para-iodoanisole 
• 124-38-9 carbon dioxide 
• 104-94-9 4-methoxy-aniline 
• 109-94-4 formic acid ethyl ester 
• 667-27-6 Ethyl bromodifluoroacetate 
• 67-66-3 chloroform 
• 1176290-05-3 C₁₃H₁₉NO 
• 149-73-5 trimethyl orthoformate 
• 100-61-8 N-methylaniline 

Downstream Products

• 85021-22-3 2-Methoxy-5,8,11-trimethyl-5,6,11,12-tetrahydro-dibenzo[b,f][1,5]diazocine 
• 764-93-2 1-decyne 
• 502925-19-1 (E)-1,2-Dichloro-N,N'-bis-(4-methoxy-phenyl)-N,N'-dimethyl-ethene-1,2-diamine 
• 701-56-4 4-methoxy-N,N-dimethylanilne 
• 1421493-01-7 N-(4-methoxyphenyl)-N-methyl-carbamoyl cyanide 
• 909132-75-8 (E)-β-(4-methoxy-N-methylanilino)acrylic acid ethyl ester 
• 643735-25-5 7-methoxy-4-(4-methoxyphenyl)-1-methylbenzo[f][1,4]-diazepine-2,3-dicarboxylic anhydride 
• 5961-59-1 N-methyl-N-(4-methoxyphenyl)amine 
• 1643531-70-7 (E)-N-[2-(6-bromopyridine-2-yl)vinyl]-4-methoxy-N-methylaniline 
• 1643531-69-4 (E)-N,N-diethyl-3-[N-(4-methoxyphenyl)-N-(methyl)amino]acrylamide 
• 1643531-68-3 (E)-4-methoxy-N-methyl-N-[(2-phenylsulfinyl)vinyl]aniline 
• 1643531-67-2 (E)-3-[N-(4-methoxyphenyl)-N-(methyl)amino]acrylonitrile 
• 1643531-59-2 (E)-tert-butyl 3-{[N-(4-methoxyphenyl)-N-(methyl)amino]}acrylate 

Relevant articles and documents

Additive-free selective methylation of secondary amines with formic acid over a Pd/In2O3 catalyst

Formic acid is used as the sole carbon and hydrogen source in the methylation of aromatic and aliphatic amines to methylamines. The reaction proceeds via a formylation/transfer hydrogenation pathway over a solid Pd/In2O3 catalyst without the need for any additive.

Borane-Trimethylamine Complex as a Reducing Agent for Selective Methylation and Formylation of Amines with CO2

We report herein that a borane-trimethylamine complex worked as an efficient reducing agent for the selective methylation and formylation of amines with 1 atm CO2 under metal-free conditions. 6-Amino-2-picoline serves as a highly efficient catalyst for the methylation of various secondary amines, whereas in its absence, the formylation of primary and secondary amines was achieved in high yield with high chemoselectivity. Mechanistic studies suggest that the 6-amino-2-picoline-borane catalytic system operates like an intramolecular frustrated Lewis pair to activate CO2.

Preparation method of formamide compound

The invention belongs to CO. 2 The invention relates to the technical field of activation conversion and related chemistry, and provides a preparation method of a formamide compound, which uses carbon dioxide. The amide compound and phenylsilane are used as raw materials, and the formamide compound is synthesized under the action of the nano porous palladium catalyst. The invention mainly provides a novel simple catalytic system and utilizes CO. 2 C1 The catalytic system has the advantages of mild reaction conditions, simple experiment operation, good functional group compatibility and the like. Because carbon dioxide is abundant, cheap and easily available and renewable C1 , The invention has great application value and social economic benefits.