5279-83-4Relevant academic research and scientific papers
Controlled Reduction of Carboxamides to Alcohols or Amines by Zinc Hydrides
Ong, Derek Yiren,Yen, Zhihao,Yoshii, Asami,Revillo Imbernon, Julia,Takita, Ryo,Chiba, Shunsuke
supporting information, p. 4992 - 4997 (2019/03/13)
New protocols for controlled reduction of carboxamides to either alcohols or amines were established using a combination of sodium hydride (NaH) and zinc halides (ZnX2). Use of a different halide on ZnX2 dictates the selectivity, wherein the NaH-ZnI2 system delivers alcohols and NaH-ZnCl2 gives amines. Extensive mechanistic studies by experimental and theoretical approaches imply that polymeric zinc hydride (ZnH2)∞ is responsible for alcohol formation, whereas dimeric zinc chloride hydride (H?Zn?Cl)2 is the key species for the production of amines.
One-pot approach for the synthesis of trans-cyclopropyl compounds from aldehydes. Application to the synthesis of GPR40 receptor agonists
Davi, Micha?l,Lebel, Hélène
supporting information; experimental part, p. 4974 - 4976 (2009/06/05)
A novel multicatalytic one-pot process providing trans-cyclopropyl compounds from corresponding aldehydes has been developed and applied to the synthesis of GPR40 small molecule agonists. The Royal Society of Chemistry.
ENHANCEMENT OF STEREOSELECTIVITY IN CATALYTIC CYCLOPROPANATION REACTIONS
Doyle, Michael P.,Loh, Kuo-Liang,DeVries, Keith M.,Chinn, Mitchell S.
, p. 833 - 836 (2007/10/02)
Significat enhancement of trans(anti) stereoselectivity is achieved in rhodium(II) acetamide catalyzed cyclopropanation reactions of 2,3,4-trimethyl-3-pentyl diazoacetate (ODA) and diazoacetamides.
