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52807-12-2 Usage


4'-Hydroxyflurbiprofen is a metabolite of Flurbiprofen (F598700), which is an anti-inflammatory drug commonly used for its analgesic properties. It is a white to off-white solid and is known for its therapeutic effects in managing pain and inflammation.


Used in Pharmaceutical Industry:
4'-Hydroxyflurbiprofen is used as an active metabolite for its anti-inflammatory and analgesic properties. It is particularly beneficial in the treatment of various conditions characterized by pain and inflammation, such as arthritis, muscle strains, and other inflammatory disorders.
Used in Research and Development:
In the field of research and development, 4'-hydroxyflurbiprofen serves as a valuable compound for studying the metabolism and pharmacological effects of Flurbiprofen. This helps in understanding the drug's mechanism of action, potential side effects, and its overall efficacy in treating specific conditions.
Used in Drug Metabolism Studies:
4'-Hydroxyflurbiprofen is used as a key metabolite in drug metabolism studies, which are crucial for assessing the safety and efficacy of medications. Understanding how the body processes and eliminates this metabolite can provide insights into the drug's pharmacokinetics and inform the development of new therapeutic agents.
Used in Quality Control and Standardization:
In the pharmaceutical industry, 4'-hydroxyflurbiprofen is used as a reference compound for quality control and standardization purposes. It helps ensure the consistency, potency, and purity of Flurbiprofen-containing products, thereby maintaining the safety and effectiveness of the medication for patients.

Check Digit Verification of cas no

The CAS Registry Mumber 52807-12-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,2,8,0 and 7 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 52807-12:
112 % 10 = 2
So 52807-12-2 is a valid CAS Registry Number.



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017


1.1 GHS Product identifier

Product name 4’-Hydroxy Flurbiprofen

1.2 Other means of identification

Product number -
Other names 4`-Hydroxy Flurbiprofen

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:52807-12-2 SDS

52807-12-2Downstream Products

52807-12-2Relevant articles and documents

CYP2C9 genotype-dependent effects on in vitro drug-drug interactions: Switching of benzbromarone effect from inhibition to activation in the CYP2C9.3 variant

Hummel, Matthew A.,Locuson, Charles W.,Gannett, Peter M.,Rock, Dan A.,Mosher, Carrie M.,Rettie, Allan E.,Tracy, Timothy S.

, p. 644 - 651 (2005)

The CYP2C9.3 variant exhibits marked decreases in substrate turnover compared with the wild-type enzyme, but little is known regarding the effect this variant form may have on the occurrence of drug-drug interactions. To examine this possibility, the effect of the potent CYP2C9 inhibitor, benzbromarone, was studied with regard to CYP2C9.1- and CYP2C9.3-mediated flurbiprofen metabolism to evaluate whether the variant enzyme exhibits differential inhibition kinetics. Although benzbromarone inhibited CYP2C9.1 activity as expected, CYP2C9.3-mediated flurbiprofen 4′-hydroxylation was activated in the presence of benzbromarone. T1 relaxation studies revealed little change in distances of flurbiprofen protons from the heme iron of either CYP2C9.1 or CYP2C9.3 in the presence of benzbromarone compared with flurbiprofen alone. Spectral binding studies were also performed to investigate whether benzbromarone affected substrate binding, with the addition of benzbromarone having little effect on flurbiprofen-binding affinity in both CYP2C9.1 and CYP2C9.3. Docking studies with the 2C9.1 structure crystallized with a closed active site identified multiple but overlapping subsites with sufficient space for benzbromarone binding in the enzyme when flurbiprofen was positioned closest to the heme. If the closed conformation of 2C9.3 is structurally similar to 2C9.1, as expected for the conservative I359L mutation, then the dynamics of benzbromarone binding may account for the switching of drug interaction effects. In conclusion, the I359L amino acid substitution found in CYP2C9.3 not only reduces metabolism compared with CYP2C9.1 but can also dramatically alter inhibitor effects, suggesting that differential degrees of drug inhibition interactions may occur in individuals with this variant form of CYP2C9. Copyright

NO-donating tacrine derivatives as potential butyrylcholinesterase inhibitors with vasorelaxation activity

Chen, Yao,Sun, Jianfei,Huang, Zhangjian,Liao, Hong,Peng, Sixun,Lehmann, Jochen,Zhang, Yihua

, p. 3162 - 3165 (2013/06/27)

To search for potent anti-Alzheimer's disease (AD) agents with multifunctional effects, 12 NO-donating tacrine-flurbiprofen hybrid compounds (2a-l) were synthesized and biologically evaluated. It was found that all the new target compounds showed selective butyrylcholinesterase (BuChE) inhibitory activity in vitro comparable or higher than tacrine and the tacrine-flurbiprofen hybrid compounds 1a-c, and released moderate amount of NO in vitro. The kinetic study suggests that one of the most active and highest BuChE selective compounds 2d may not only compete with the substrate for the same catalytic active site (CAS) but also interact with a second binding site. Furthermore, 2d and 2l exhibited significant vascular relaxation effect, which is beneficial for the treatment of AD. All the results suggest that 2d and 2l might be promising lead compounds for further research.

Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of β-amyloid1-42 secretion

Peretto, Ilaria,Radaelli, Stefano,Parini, Carlo,Zandi, Michele,Raveglia, Luca F.,Dondio, Giulio,Fontanella, Laura,Misiano, Paola,Bigogno, Chiara,Rizzi, Andrea,Riccardi, Benedetta,Biscaioli, Marcello,Marchetti, Silvia,Puccini, Paola,Catinella, Silvia,Rondelli, Ivano,Cenacchi, Valentina,Bolzoni, Pier Tonino,Caruso, Paola,Villetti, Gino,Facchinetti, Fabrizio,Del Giudice, Elda,Moretto, Nadia,Imbimbo, Bruno P.

, p. 5705 - 5720 (2007/10/03)

Flurbiprofen, a nonsteroidal antiinflammatory drug (NSAID), has been recently described to selectively inhibit β-amyloid1-42 (Aβ42) secretion, the most toxic component of the senile plaques present in the brain of Alzheimer patients. The use of this NSAID in Alzheimer's disease (AD) is hampered by a significant gastrointestinal toxicity associated with cyclooxygenase (COX) inhibition. New flurbiprofen analogues were synthesized, with the aim of increasing Aβ42 inhibitory potency while removing anti-COX activity. In vitro ADME developability parameters were taken into account in order to identify optimized compounds at an early stage of the project. Appropriate substitution patterns at the alpha position of flurbiprofen allowed for the complete removal of anti-COX activity, while modifications at the terminal phenyl ring resulted in increased inhibitory potency on Aβ42 secretion. In rats, some of the compounds appeared to be well absorbed after oral administration and to penetrate into the central nervous system. Studies in a transgenic mice model of AD showed that selected compounds significantly decreased plasma Aβ42 concentrations. These new flurbiprofen analogues represent potential drug candidates to be developed for the treatment of AD.

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