52817-50-2Relevant academic research and scientific papers
Rhodium(I)-Catalyzed Aryl C-H Carboxylation of 2-Arylanilines with CO2
Gao, Yuzhen,Cai, Zhihua,Li, Shangda,Li, Gang
supporting information, p. 3663 - 3669 (2019/05/17)
An unprecedented Rh(I)-catalyzed, amino-group-assisted C-H carboxylation of 2-arylanilines with CO2 under redox-neutral conditions has been developed. This reaction was promoted by a phosphine ligand with t-BuOK as the base and did not require the use of additional strong organometallic reagent. It enabled an efficient direct conversion of a broad range of 2-(hetero)arylanilines including electron-deficient heteroarenes to various phenanthridinones. Possible intermediates of the reaction were also evaluated in the preliminary mechanistic studies.
Facile Synthesis of Phenanthridinone Alkaloids via Suzuki–Miyaura Cross-coupling
Kuwata, Yoshiyuki,Sonoda, Motohiro,Tanimori, Shinji
, p. 1645 - 1651 (2017/03/27)
Phenanthridinone alkaloids crinasiadine 1 and N-alkylcrinasiadines 6, 7, 8, 9, 10 have been synthesized based on palladium-catalyzed tandem C–C and C–N bond formation starting from 2-aminophenylboronic acid and 2-bromobenzoate in short steps. Related alka
A new, direct, and efficient synthesis of benzonaphthyridin-5-ones
Cailly, Thomas,Fabis, Frédéric,Rault, Sylvain
, p. 5862 - 5867 (2007/10/03)
Microwave-assisted Suzuki cross-coupling reaction of 2-fluorophenylboronic acid with all orthochlorocyanopyridine isomers allowed the rapid syntheses of key intermediates for anionic ring closure, which was performed using potassium hydroxide under microwave irradiation to give benzonaphthyridin-5-ones in high yields.
Design and synthesis of poly ADP-ribose polymerase-1 inhibitors. 2. Biological evaluation of aza-5[H]-phenanthridin-6-ones as potent, aqueous-soluble compounds for the treatment of ischemic injuries
Ferraris, Dana,Ko, Yao-Sen,Pahutski, Thomas,Ficco, Rica Pargas,Serdyuk, Larisa,Alemu, Christina,Bradford, Chadwick,Chiou, Tiffany,Hoover, Randall,Huang, Shirley,Lautar, Susan,Liang, Shi,Lin, Qian,Lu, May X.-C.,Mooney, Maria,Morgan, Lisa,Qian, Yongzhen,Tran, Scott,Williams, Lawrence R.,Wu, Qi Yi,Zhang, Jie,Zou, Yinong,Kalish, Vincent
, p. 3138 - 3151 (2007/10/03)
A series of aza-5[H]-phenanthridin-6-ones were synthesized and evaluated as inhibitors of poly ADP-ribose polymerase-1 (PARP-1). Inhibitory potency of the unsubstituted aza-5[H]-phenanthridin-6-ones (i.e., benzonaphthyridones) was dependent on the positio
