528584-52-3

Basic information

• Product Name: 9H-fluoren-9-ylmethyl [(2S)-1-({2-[(tert-butoxycarbonyl)amino]ethyl} amino)-1-oxo-3-phenylpropan-2-yl]carbamate
• Synonyms: 9H-fluoren-9-ylmethyl [(2S)-1-({2-[(tert-butoxycarbonyl)amino]ethyl} amino)-1-oxo-3-phenylpropan-2-yl]carbamate
• CAS NO: 528584-52-3
• Molecular Weight: 529.636
• Mol File: 528584-52-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 9H-fluoren-9-ylmethyl [(2S)-1-({2-[(tert-butoxycarbonyl)amino]ethyl} amino)-1-oxo-3-phenylpropan-2-yl]carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: 9H-fluoren-9-ylmethyl [(2S)-1-({2-[(tert-butoxycarbonyl)amino]ethyl} amino)-1-oxo-3-phenylpropan-2-yl]carbamate(528584-52-3)
• EPA Substance Registry System: 9H-fluoren-9-ylmethyl [(2S)-1-({2-[(tert-butoxycarbonyl)amino]ethyl} amino)-1-oxo-3-phenylpropan-2-yl]carbamate(528584-52-3)

Safety Data

• Hazardous Substances Data: 528584-52-3(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 57260-73-8 N-BOC-1,2-diaminoethane 
• 35661-40-6 N-Fmoc L-Phe 
• 7087-68-5 N-ethyl-N,N-diisopropylamine 

Downstream Products

• 383187-88-0 N-[2-(tert-butoxycarbonylamino)ethyl]-2-(S)-amino-3-phenylpropionamide 

Relevant articles and documents

Naphthoquinone amino acid derivatives, synthesis and biological activity as proteasome inhibitors

The ubiquitin-proteasome system has been largely investigated for its key role in protein degradation mechanisms that regulate both apoptosis and cell division. Because of their antitumour activity, different classes of proteasome inhibitors have been identified to date. Some of these compounds are currently employed in the clinical treatment of several types of cancer among which multiple myeloma. Here, we describe the design, chemistry, biological activity and modelling studies of a large series of amino acid derivatives linked to a naphthoquinone pharmacophoric group through variable spacers. Some analogues showed interesting inhibitory potency for the β1 and β5 subunits of the proteasome with IC50 values in the sub-μm range.

CYTOTOXIC PEPTIDES AND ANTIBODY DRUG CONJUGATES THEREOF

The present invention is directed to cytotoxic pentapeptides, to antibody drug conjugates thereof, and to methods for using the same to treat cancer.