528836-52-4

Upstream product

• 244247-69-6 4-bis(2'-hydroxyethyl)amino-N-tert-butyloxycarbonylaniline 
• 7143-01-3 Methanesulfonic anhydride 
• 24424-99-5 di-tert-butyl dicarbonate 
• 7575-35-1 N,N-bis(2-hydroxyethyl)-4-aminoaniline 
• 18226-17-0 N,N-bis(2-hydroxyethyl)-4-nitroaniline 
• 304015-62-1 N,N-bis(2-{[tert-butyldimethylsilyl]oxy}ethyl)-1,4-benzenediamine 
• 304015-61-0 N,N-bis(2-{[tert-butyldimethylsilyl]oxy}ethyl)-4-nitroaniline 
• 244247-70-9 4-bis(2'-tert-butyldimethylsilyloxyethyl)amino-N-tert-butyloxycarbonylaniline 
• 124-63-0 methanesulfonyl chloride 
• 54381-16-7 N,N-bis(2-hydroxyethyl)-1,4-phenylenediamine sulfate 

Downstream Products

• 528836-64-8 4-bis(2'-bromoethyl)amino-N-tert-butyloxycarbonylaniline 
• 528836-58-0 4-bis(2'-iodoethyl)amino-N-tert-butyloxycarbonylaniline 

Relevant academic research and scientific papers

Introducing a squaramide-based self-immolative spacer for controlled drug release

Herein we report the design, synthesis and assessment of the first example of a squaramide-based self-immolative system triggered by an enzymatic reduction. We have proved that the release of the alkylating agentN′,N′-(bis(2-chloroethyl)benzene)-1,4-diamine (ANM) provokes a dramatic reduction of the survival factor in glioblastoma cells, evidencing the suitability of the squaramide-based spacer for drug delivery applications.

Self-immolative nitrogen mustards prodrugs cleavable by carboxypeptidase G2 (CPG2) showing large cytotoxicity differentials in GDEPT

Nineteen novel potential self-immolative prodrugs and their corresponding drugs have been synthesized for gene-directed enzyme prodrug therapy (GDEPT) with carboxypeptidase G2 (CPG2) as the activating enzyme. The compounds are derived from o- and p-amino