((4-((tert-butoxycarbonyl)amino)phenyl)azanediyl)bis(ethane-2,1-diyl) dimethanesulfonate

Base Information

Chemical Name:((4-((tert-butoxycarbonyl)amino)phenyl)azanediyl)bis(ethane-2,1-diyl) dimethanesulfonate
CAS No.:528836-52-4
Molecular Formula:C₁₇H₂₈N₂O₈S₂
Molecular Weight:452.55
Hs Code.:

Synonyms:((4-((tert-butoxycarbonyl)amino)phenyl)azanediyl)bis(ethane-2,1-diyl) dimethanesulfonate

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Chemical Property of ((4-((tert-butoxycarbonyl)amino)phenyl)azanediyl)bis(ethane-2,1-diyl) dimethanesulfonate

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Technology Process of ((4-((tert-butoxycarbonyl)amino)phenyl)azanediyl)bis(ethane-2,1-diyl) dimethanesulfonate

There total 9 articles about ((4-((tert-butoxycarbonyl)amino)phenyl)azanediyl)bis(ethane-2,1-diyl) dimethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 124-63-0
methanesulfonyl chloride

: 244247-69-6
4-bis(2'-hydroxyethyl)amino-N-tert-butyloxycarbonylaniline

: 528836-52-4
((4-((tert-butoxycarbonyl)amino)phenyl)azanediyl)bis(ethane-2,1-diyl) dimethanesulfonate

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 0.5h; Inert atmosphere;
DOI:10.1039/d0cc07683j

Reference yield: 57.0%

: 244247-69-6
4-bis(2'-hydroxyethyl)amino-N-tert-butyloxycarbonylaniline

: 7143-01-3
Methanesulfonic anhydride

: 528836-52-4
((4-((tert-butoxycarbonyl)amino)phenyl)azanediyl)bis(ethane-2,1-diyl) dimethanesulfonate

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1021/jm020462i

Reference yield:

: 18226-17-0
N,N-bis(2-hydroxyethyl)-4-nitroaniline

: 528836-52-4
((4-((tert-butoxycarbonyl)amino)phenyl)azanediyl)bis(ethane-2,1-diyl) dimethanesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1: 89 percent / imidazole / dimethylformamide / 20 h / 20 °C

2: 95 percent / H₂ / Pd/C / tetrahydrofuran / 6 h

3: 100 percent / tetrahydrofuran / 16 h / 20 °C

4: 69 percent / triethylamine trihydrofluoride / tetrahydrofuran / 20 °C

5: 57 percent / 4-(N,N-dimethyl)aminopyridine; Et₃N / CH₂Cl₂ / 20 °C

With 1H-imidazole; dmap; triethylamine trihydrofluoride; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm020462i