5292-72-8

Basic information

• Product Name: 2-(4-chlorophenyl)-N,N-diethylacetamide
• Synonyms: 2-(4-chlorophenyl)-N,N-diethylacetamide
• CAS NO: 5292-72-8
• Molecular Weight: 225.718
• Mol File: 5292-72-8.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2-(4-chlorophenyl)-N,N-diethylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-chlorophenyl)-N,N-diethylacetamide(5292-72-8)
• EPA Substance Registry System: 2-(4-chlorophenyl)-N,N-diethylacetamide(5292-72-8)

Safety Data

• Hazardous Substances Data: 5292-72-8(Hazardous Substances Data)

Upstream product

• 1878-66-6 4-chlorophenylacetic Acid 
• 109-89-7 diethylamine 
• 106-39-8 bromochlorobenzene 
• 685-91-6 diethylacetamide 
• 25026-34-0 4-chlorophenacetyl chloride 
• 1497283-43-8 C₁₂H₁₆ClNO 
• 58784-40-0 4-chlorophenyl isocyanate 

Downstream Products

• 1610734-25-2 2-(4-(tert-butyl)phenyl)-2-(4-chlorophenyl)-N,N-diethylacetamide 
• 1875-88-3 2-(4-Chlorophenyl)ethanol 
• 137958-84-0 2-(4-chlorophenyl)-N,N-diethylacrylamide 
• 1598387-25-7 2-(4-chlorophenyl)-N,N-diethyl-3,3-difluoro-3-(trimethylsilyl)propanamide 

Relevant articles and documents

Preparation method of aryl acetamide compound

The invention discloses a preparation method of an aryl acetamide compound. The method comprises the following steps: adding a palladium catalyst, a ligand, benzyl formate, tertiary amine and trifluoroacetic anhydride into an organic solvent, performing reacting at 130 DEG C for 24 hours, and after the reaction is completed, carrying out after-treatment to obtain the aryl acetamide compound. The preparation method is easy to operate, the after-treatment is simple and convenient, reaction initial raw materials are cheap and easily available, benzyl formate is taken as both a carbon monoxide source and a reactant, tertiary amine is taken as an amine source, substrate designability is high, substrate functional group tolerance range is wide, and reaction efficiency is high. What is noteworthyis that C-N bonds of the tertiary amine are broken in the reaction, no extra oxidizing agent is needed, various aryl acetamide compounds can be synthesized according to actual needs, and practicability is high.

A general and practical palladium-catalyzed direct a-arylation of amides with aryl halides

An efficient system for the direct catalytic intermolecular α-arylation of acetamide derivatives with aryl bromides and chlorides is presented. The palladium catalyst is supported by Kwong's indolebased phosphine ligand and provides monoarylated amides in up to 95% yield. Excellent chemoselectivities (>10:1) in the mono- and diarylation with aryl bromides were achieved by careful selection of bases, solvents, and stoichiometry. Under the coupling conditions, the weakly acidic α-protons of amides (pK a up to 35) were reversibly depotonated by lithium tert-butoxide (LiO-t-Bu), sodium tert-butoxide (NaO-t-Bu) or sodium bis(trimethylsilyl)amide [NaN(SiMe3)2].

Palladium-catalyzed intermolecular α-arylation of zinc amide enolates under mild conditions

The intermolecular α-arylation and vinylation of amides by palladium-catalyzed coupling of aryl bromides and vinyl bromides with zinc enolates of amides is reported. Reactions of three different types of zinc enolates have been developed. The reactions of