137958-84-0Relevant academic research and scientific papers
Palladium-Catalyzed Hydroaminocarbonylation of Alkynes with Tertiary Amines via C-N Bond Cleavage
Gao, Bao,Huang, Hanmin
, p. 6260 - 6263 (2017)
An efficient strategy for the cleavage of the C-N bond of tertiary amines was developed with DTBP as an oxidant, in which the cleaved H atom and amine moiety were successfully transferred to the desired products. This strategy has enabled an efficient palladium-catalyzed hydroaminocarbonylation of alkynes with tertiary amines. Notably, the catalyst loading could be lowered from 5 to 0.1 mol %, which represents the lowest catalyst loading among the reported work on carbonylation via C-N bond activation.
P450-catalyzed asymmetric cyclopropanation of electron-deficient olefins under aerobic conditions
Renata, Hans,Wang, Z. Jane,Kitto, Rebekah Z.,Arnold, Frances H.
, p. 3640 - 3643 (2015/02/05)
A variant of P450 from Bacillus megaterium five mutations away from wild type is a highly active catalyst for cyclopropanation of a variety of acrylamide and acrylate olefins with ethyl diazoacetate (EDA). The very high rate of reaction enabled by histidine ligation allowed the reaction to be conducted under aerobic conditions. The promiscuity of this catalyst for a variety of substrates containing amides has enabled synthesis of a small library of precursors to levomilnacipran derivatives. This journal is
Organic Iodide Aided Carbonylation of Terminal Acetylenes with Palladium Catalyst
Torii, Sigeru,Okumoto, Hiroshi,Sadakane, Masahiro,He Xu, Long
, p. 1673 - 1676 (2007/10/02)
Carbonylation of various terminal acetylenes in the presence of a catalytic amount of organic iodides or amine * HI salt and palladium complexes was found to produce 2-substituted acrylamides in good yields under mild conditions (5 atm, 120 deg C, 6h).
