5300-21-0

Basic information

• Product Name: N,N-Diethylphenethylamine
• Synonyms: N,N-Diethyl-2-phenylethanamine;N,N-Diethylbenzeneethanamine;N,N-Diethylphenethylamine;N,N-DIETHYL-2-PHENYLETHYLAMINE HCL;Benzeneethanamine, N,N-diethyl-,
• CAS NO: 5300-21-0
• Molecular Formula: C₁₂H₁₉N
• Molecular Weight: 177.28596
• Mol File: 5300-21-0.mol
• Article Data: 20

Chemical Properties

• Boiling Point: 137-139℃ (23 Torr)
• Appearance: /
• CAS DataBase Reference: N,N-Diethylphenethylamine(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-Diethylphenethylamine(5300-21-0)
• EPA Substance Registry System: N,N-Diethylphenethylamine(5300-21-0)

Safety Data

• Hazardous Substances Data: 5300-21-0(Hazardous Substances Data)

Usage

General Description

N,N-Diethylphenethylamine, also known as N,N-DEPEA, is a psychoactive compound belonging to the phenethylamine class of chemicals. It is a derivative of amphetamine and acts as a stimulant, affecting the central nervous system. N,N-DEPEA is known to increase levels of neurotransmitters such as dopamine and norepinephrine, leading to heightened alertness and mood elevation. This chemical has been linked to potential adverse effects on cardiovascular health, as it can increase heart rate and blood pressure. N,N-DEPEA is often found in dietary supplements and weight loss products, but its use and sale have been banned or restricted in many countries due to safety concerns and lack of regulatory approval.

Upstream product

• 2431-96-1 N,N-diethylphenylacetamide 
• 140-29-4 phenylacetonitrile 
• 109-89-7 diethylamine 
• 103-63-9 1-phenyl-2-bromoethane 
• 13125-60-5 butoxymethyldiethylamine 
• 6921-34-2 benzylmagnesium chloride 
• 76123-47-2 N-(1H-1,2,3-benzotriazol-1-ylmethyl)-N,N-diethyl-amine 
• 64-17-5 ethanol 
• 64-04-0 phenethylamine 
• 75-05-8 acetonitrile 
• 101-97-3 Ethyl 2-phenylethanoate 
• 82489-29-0 (E)-N,N-diethyl-2-phenylethen-1-amine 
• 536-74-3 phenylacetylene 
• 100-44-7 benzyl chloride 

Downstream Products

• 860767-75-5 ethyl-phenethyl-carbamonitrile 
• 74-96-4 ethyl bromide 
• 103-63-9 1-phenyl-2-bromoethane 
• 1021877-97-3 C₁₂H₁₇⁽²⁾H₂N 
• 1670-17-3 N,N-dimethyl-2,4-dinitroaniline 
• 22002-68-2 N-ethyl-2-phenylethanamine 
• 64049-55-4 triethyl-phenethyl-ammonium; iodide 
• 1665-60-7 diethyl-(4-amino-phenethyl)-amine 

Relevant articles and documents

Synthesis of Arylethylamines via C(sp3)-C(sp3) Palladium-Catalyzed Cross-Coupling

Substituted arylethylamines represent a key structural motif in natural, pharmaceutical, and agrochemical compounds. Access to such scaffolds has been the subject of long-standing synthetic interest. Herein, we report the synthesis of such scaffolds via a palladium-catalyzed C(sp3)-C(sp3) coupling between (chloromethyl)aryls and air-/moisture-stable N,N-dialkylaminomethyltrifluoroborate salts. Rapid hit identification was achieved using microscale high-throughput experimentation and was followed by millimolar-scale reaction parameter optimization. A range of structurally and electronically varied arylethylamine products were obtained in moderate to excellent yields (27-96%, >60 examples). The reaction mechanism is proposed to proceed via formation of a trialkylbenzylammonium species prior to oxidative addition.

AlCl3 immobilized on silicic acid as efficient Lewis acid catalyst for highly selective preparation of dicyclohexylamine from the vapor phase hydroamination of cyclohexene with cyclohexylamine

An efficient and stable Lewis acid catalyst silicic acid (SA)-immobilized AlCl3 (AlCl3-SA) has been successfully prepared by the chemical bonding method in this work. The results indicated that the immobilized 15percentAlCl3-SA exhibited excellent catalytic performance and stability in the vapor phase hydroamination of cyclohexene with cyclohexylamine. 58.5percent cyclohexene conversion with 98.7percent selectivity to dicyclohexylamine was still maintained after running for over 150 h, and the space time yield of dicyclohexylamine was 142.6 mol/h·m3. The developed AlCl3-SA catalyst had the advantages of low cost and long-time stable activity. Maybe this work provides a promising approach for hydroamination of olefins to amines.

Lithium-Catalyzed anti-Markovnikov Intermolecular Hydroamination Reactions of Vinylarenes and Simple Secondary Amines

Various β-arylethylamine derivatives were straightforwardly obtained by the lithium-catalyzed anti-Markovnikov selective intermolecular hydroamination reaction of secondary aliphatic amines with vinylarenes. The use of only 1.5 mol % LiCH2TMS as a solid base in THF proved to be efficient to deliver the target products at room temperature with up to complete conversions. Both reaction partners were, moreover, used in equivalent amounts; thus, this protocol best respects the concepts of sustainable chemistry for the easy preparation of lead structures for pharmaceutically active compounds.