53007-43-5

Upstream product

• 7647-01-0 hydrogenchloride 
• 90-01-7 salicylic alcohol 
• 106-48-9 4-chloro-phenol 
• 89694-48-4 5-chloro-2-methoxyphenyl boronic acid 
• 52289-93-7 o-Methoxybenzyl bromide 
• 2467-02-9 Bis(2-hydroxyphenyl)methane 
• 915697-30-2 4-chloro-1-methoxy-2-(2-methoxy-benzyl)-benzene 
• 132980-32-6 2-(1H-1,2,3-benzotriazol-1-ylmethyl)phenol 

Downstream Products

• 71840-29-4 bis-(2-benzoyloxy-phenyl)-methane 
• 92-83-1 xanthene 
• 2467-02-9 Bis(2-hydroxyphenyl)methane 

Relevant academic research and scientific papers

Synthesis and antimicrobial activities of halogenated bis(hydroxyphenyl)methanes

A series of halophenols was prepared by the reaction of bis(hydroxyphenyl)methanes with effective halogenating agents such as bromine and sulfuryl chloride. One of these compounds, a biologically active halophenol-2,2′,3,3′-tetrabromo-4,4′,5,5′-tetrahydroxydiphenylmethane (1)-frequently isolated from red algae, was synthesized for the first time. Other halophenols included several novel compounds, together with known derivatives that were synthesized from the phenolic intermediates, bis(3,4-dihydroxyphenyl)methane (5) and bis(2-hydroxyphenyl)methane (14). All of the synthesized compounds were tested for antimicrobial activity against Gram-positive, Gram-negative bacteria and fungi. The preliminary structure-activity relationship was investigated in order to determine the essential structural requirements for their antimicrobial activity. Of all these halophenols, 2,2′,3,3′,6-pentabromo-4,4′,5,5′-tetrahydroxydiphenylmethane (8) was found to be the most active against Candida albicans, Aspergillus fumigatus, Trichophyton rubrum, and Trichophyton mentagrophytes while 3,3′,5,5′-tetrachloro-2,2′-dihydroxydiphenylmethane (18) exerted a powerful antibacterial effect against Staphylococcus aureus, Bacillus subtilis, Micrococcus luteus, Proteus vulgaris, and Salmonella typhimurium.

ORGANIC COMPOUNDS

A compound of formula (I); in free or pharmaceutically acceptable salt form, where R1, R2, R3, R4, R5, m, n, w, X, Y and Q have the meanings as indicated in the specification, are useful for treating conditions mediated by the CRTh2 receptor, especially inflammatory or obstructive airways diseases.

o-(α-Benzotriazolylalkyl)phenols: Novel Precursors for the Preparation of 1,1-Bis(2-hydroxyaryl)alkanes

Reactions of o-(α-benzotriazolylalkyl)phenols with a variety of substituted phenols and naphthols in the presence of a base provide efficient access to symmetrical and more importantly to unsymmetrical 1,1-bis(2-hydroxyaryl)alkanes.