530080-17-2

Usage

Uses

Used in Organic Synthesis:
4-(2,2,2-TRIFLUOROETHOXY)IODOBENZENE is utilized as a reagent in organic synthesis for its capacity to introduce an iodo group into other organic compounds. This property is particularly valuable for the formation of new chemical bonds and the synthesis of complex organic molecules.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 4-(2,2,2-TRIFLUOROETHOXY)IODOBENZENE is employed as a reagent to facilitate the creation of pharmaceuticals. Its ability to modify the structure of organic compounds makes it instrumental in the development of new drugs and the enhancement of existing ones.
Used in the Development of High-Value Organic Molecules:
4-(2,2,2-TRIFLUOROETHOXY)IODOBENZENE is also used in the synthesis of high-value organic molecules outside the realm of pharmaceuticals. Its versatility allows it to contribute to the advancement of various chemical and material sciences applications.
Used in Research:
4-(2,2,2-TRIFLUOROETHOXY)IODOBENZENE serves as an important tool for researchers, providing them with a means to explore the chemical properties and reactivity of the iodo and trifluoroethoxy groups within the context of different chemical systems.

Upstream product

• 353-83-3 1,1,1-trifluoro-2-iodoethane 
• 540-38-5 p-Iodophenol 
• 75-89-8 2,2,2-trifluoroethanol 
• 5122-99-6 4-iodophenylboronic acid 

Relevant academic research and scientific papers

Metal-free transfer hydrochlorination of internal C-C triple bonds with a bicyclo[3.1.0]hexane-based surrogate releasing two molecules of hydrogen chloride

The development and application of a transfer hydrochlorination reagent based on a trichlorinated bicyclo[3.1.0]hexane core that transfers two molecules of HCl per molecule of surrogate to a π-basic substrate under B(C6F5)3 catalysis is reported. Lewis acid-assisted chloride abstraction followed by thermal electrocyclic cyclopropyl-to-allyl cation ring opening releases ring strain as a previously unexploited driving force.

Copper-catalyzed oxidative trifluoroethoxylation of aryl boronic acids with CF3CH2OH

A mild and efficient copper-catalyzed oxidative trifluoroethoxylation of aryl and heteroaryl boronic acids with CF3CH2OH has been developed. This protocol tolerates a range of functional groups, allowing access to a variety of aryl and heteroaryl trifluoroethyl ethers.

Method for preparing aryl trifluoroethoxyl ether

The invention relates to a method for preparing aryl trifluoroethoxyl ether. The method includes the steps that aryl boron compounds and trifluoroethanol are added to organic solvent, a copper salt catalyst, a ligand and an oxidizing agent are added, a reaction is conducted in a stirring mode for 1-40 hours at the temperature of 0-60 DEG C, filtering is conducted, column chromatography isolation is conducted, and the aryl trifluoroethoxyl ether is obtained. The method is simple in operation, raw materials are easy to obtain, the reaction condition is mild, the substrate universality is wide, the environmental friendliness is achieved, and the method is applicable to industrial application.