532-43-4 Usage
Description
Different sources of media describe the Description of 532-43-4 differently. You can refer to the following data:
1. Thiamine nitrate is the thiamine salt formed from one mole of thiamine base and one mole of nitric acid. It occurs as an anhydrous crystalline solid of low hygroscopicity. Thiamin (vitamin B1) is a member of the vitamin B complex. Attributing to low hydroscopicity, thiamine nitrate works as a more stable form of thiamine in pharmaceutical preparations.
Thiamine nitrate is preferred to be used for the preparation of multivitamins and as a food fortification in dry blends and dry products such as in wheat flour.
2. Thiamine is a water-soluble vitamin with antioxidant, neuroprotective, and anxiolytic properties. It inhibits lipid peroxidation in rat liver microsomes and free radical oxidation of oleic acid in vitro when used at concentrations ranging from 1 to 100 μM. In vivo, thiamine (100 mg/kg) reduces hepatic levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT), lipid peroxidation, and protein damage in a rat model of acute ethanol intoxication. It reverses predator stress-induced suppression of hippocampal neurogenesis and decreases the latency of step-down from a platform, indicating anxiolytic-like activity in mice. Thiamine (8.5 mg/100 g food) reduces neurodegeneration and increases survival in Slc19a3-/- mice, a model of thiamine metabolism dysfunction syndrome-2 (THMD-2).
References
[1] Food and Agriculture Organization of the United Nations, Food Fortification: Technology and Quality Control: Report of an FAO technical meeting Rome, 1995
[2] Ronald R. Eitenmiller, W. O. Landen Jr and Lin Ye, Vitamin Analysis for the Health and Food Sciences, Second Edition, 2008
[3] Thomas J. Macek, Beate A. Feller and Edward J. Hanus, Pharmaceutical studies with thiamine mononitrate, Journal of Pharmaceutical Sciences, 1950, vol. 39, 365-369
Uses
Different sources of media describe the Uses of 532-43-4 differently. You can refer to the following data:
1. Thiamine Nitrate is an orally administered vitamin. Thiamine is a essential nutrient required for carbohydrate metabolism and is involved in nerve function.
2. Vitamin B1.
General Description
Certified pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Thiamine Nitrate is a mononitrate salt of thiamine. It is synthesized from thiamine hydrochloride following a sequence of steps. Thiamine Nitrate is used as a dietary supplement in crackers, eggs substitute and enriched flour.
Safety Profile
Poison by intravenous
and intraperitoneal routes. A powerful
oxidizer. When heated to decomposition it emits very toxic fums of SOx, and NOx. See also NITRATES.
Check Digit Verification of cas no
The CAS Registry Mumber 532-43-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,3 and 2 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 532-43:
(5*5)+(4*3)+(3*2)+(2*4)+(1*3)=54
54 % 10 = 4
So 532-43-4 is a valid CAS Registry Number.
InChI:InChI=1/C12H17N4OS.NO3/c1-8-11(3-4-17)18-7-16(8)6-10-5-14-9(2)15-12(10)13;2-1(3)4/h5,7,17H,3-4,6H2,1-2H3,(H2,13,14,15);/q+1;-1
532-43-4Relevant articles and documents
Thiamin Acetate, C12H17N4OS+.C2H3O2-
Casas, Jose S.,Castineiras, Alfonso,Couce, Maria D.,Sordo, Jose,Varela, Jose M.
, p. 1265 - 1267 (1994)
In thiamin acetate crystals, the thiamin cation -5-(2-hydroxyethyl)-4-methylthiazolium> adopts the usual F conformation, with torsion angles C5'-C3,5'-N3-C2 and N3-C3,5-C5'-C4' (between the pyridinyl and thiazolium moieties) of 5.6(7) and -83.5(6) deg, respectively.Hydrogen bonds involving the O5γ-H hydroxyl and N4α'-H2 amine groups and the N1' and N3' pyrimidine atoms interconnect the thiamin cations.The acetate anions are hydrogen bonded to the N4α'-H2 group and probably also to the C2-H group of the thiazole ring.
A nitric-acid thiamine new synthesis mode (by machine translation)
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Paragraph 0015; 0016; 0017; 0018, (2018/05/01)
The invention discloses a method for nitric acid thiamine new synthesis mode, characterized in that the sulfur on behalf of the thiamine by hydrogen peroxide oxidation of oxidizing liquid, rotation of calcium salt, to obtain calcium sulphate solids separation, then the use of ammonia and in [...], get the nitric acid thiamine, after separation, in the mother liquor contains only ammonium sulfate, through three-effect evaporation to obtain pure ammonium sulfate. The invention disclosed nitric acid thiamine new synthetic way improves the traditional view of converting the ammonium nitrate, calcium transfer salt, not only in the yield and quality has not been affected, but also for later mother liquor and processing has the great advantage of, there is a by-product calcium sulfate generation, there is a pure ammonium sulfate generation, can solve the traditional process the mother liquor in the thiamine nitrate high ammonia nitrogen situation. (by machine translation)
