CAS No.532-43-4,Thiamine nitrate Suppliers

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Basic Information

Molecular Structure:
CAS No.:	532-43-4
Name:	Thiamine nitrate
Article Data:	6

Formula:	C₁₂H₁₇N₅O₄S
Molecular Weight:	327.364
Synonyms:	Thiaminenitrate (6CI);Thiamine nitrate (salt) (7CI,8CI);Thiazolium,3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methyl-,nitrate (salt) (9CI);3-(4-Amino-2-methylpyrimidyl-5-methyl)-4-methyl-5,b-hydroxyethylthiazolium nitrate;Aneurine mononitrate;Aneurine-nitrate;Betabion mononitrate;Vitamin B1mononitrate;Vitamin B1 nitrate;Vitamin B1 mononitrate;Thiazolium,3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methyl-,nitrate (1:1);Thiamine mononitrate;
EINECS:	208-537-4
Melting Point:	196-200 °C
Appearance:	white crystal powder
Safety:	22-24/25
PSA:	173.03000
LogP:	1.47300

Synthetic route

: thiamine sulfate

: 532-43-4
vitamin B1 mononitrate

Conditions

Conditions	Yield
With ammonium hydroxide; nitric acid at 10℃; for 3.5h; pH=7 - 8; Temperature; pH-value;	94.56%

: 299-35-4
3-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-5-(2-hydroxy-ethyl)-4-methyl-3H-thiazole-2-thione

: 532-43-4
vitamin B1 mononitrate

Conditions

Conditions	Yield
With dihydrogen peroxide; nitric acid

: 67-03-8
Thiamine hydrochloride

: 532-43-4
vitamin B1 mononitrate

Conditions

Conditions	Yield
With sodium hydroxide; silver nitrate In water

: 70-16-6
Aneurin

: 532-43-4
vitamin B1 mononitrate

Conditions

Conditions	Yield
With dihydrogen peroxide; nitric acid In water at 20℃; pH=3.5;

: 2380-61-2
thiamine sulfate

: 532-43-4
vitamin B1 mononitrate

Conditions

Conditions	Yield
With ammonium nitrate; ammonium hydroxide for 0.25h; pH=7.3; Reagent/catalyst; pH-value;	47.92 g

: 532-43-4
vitamin B1 mononitrate

: 65-46-3
CYTIDINE

: 2-methyl-8-ribosylcytosichrome

Conditions

Conditions	Yield
In methanol for 3h; Heating;	40%

: 532-43-4
vitamin B1 mononitrate

: <5,12,19,26,33,40-hexaamino-3,10,17,24,31,38-hexamethyl<1.6>(1,5)pyrimidiniophane> hexanitrate

Conditions

Conditions	Yield
In methanol for 2h; Heating;	34%
In methanol for 2h; Heating;

: 75-44-5
phosgene

: 532-43-4
vitamin B1 mononitrate

: 96793-20-3
3-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-5-(2-chlorocarbonyloxy-ethyl)-4-methyl-thiazolium; chloride

Conditions

Conditions	Yield
In acetic acid at -10℃;

: 532-43-4
vitamin B1 mononitrate

: 74-88-4
methyl iodide

: N1'-methylthiaminium diiodide

Conditions

Conditions	Yield
In methanol

Raw Materials

299-35-4

67-03-8

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Chemistry

Molecular Structure of Thiamine mononitrate (CAS NO.532-43-4):

Molecular Formula: C₁₂H₁₇N₅O₄S
Molecular Weight: 327.3595
IUPAC Name: 2-[3-[(4-Amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-3-ium-5-yl]ethanol nitrate
EINECS: 208-537-4
Classification Code: Vitamin [enzyme co-factor]
Melting point: 196-200 °C
H bond acceptors: 5
H bond donors: 3
Freely Rotating Bonds: 5
Product Categories: Biochemistry; Vitamins; Vitamins and derivatives
Stability: Stable. Incompatible with strong oxidizing agents.

Uses

Thiamine mononitrate (CAS NO.532-43-4) is applicable to vitamin B1 deficiency, maintain normal metabolism and nerve conduction function. It is also used in adjuvant therapy for indigestion, neuropathy, etc.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	intravenous	350mg/kg (350mg/kg)		Drugs in Japan Vol. 6, Pg. 449, 1982.
mouse	LD	oral	> 5gm/kg (5000mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 42, Pg. 114, 1992.
mouse	LD50	intraperitoneal	387mg/kg (387mg/kg)	BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Proceedings of the Society for Experimental Biology and Medicine. Vol. 68, Pg. 153, 1948.
mouse	LD50	intravenous	84mg/kg (84mg/kg)	BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Proceedings of the Society for Experimental Biology and Medicine. Vol. 68, Pg. 153, 1948.
rabbit	LD50	intravenous	113mg/kg (113mg/kg)	BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: CYANOSIS LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Proceedings of the Society for Experimental Biology and Medicine. Vol. 68, Pg. 153, 1948.
rabbit	LD50	intravenous	300mg/kg (300mg/kg)		Drugs in Japan Vol. 6, Pg. 449, 1982.

Consensus Reports

Reported in EPA TSCA Inventory.

Safety Profile

Poison by intravenous and intraperitoneal routes. A powerful oxidizer. When heated to decomposition it emits very toxic fumes of NO_x and SO_x.
Safety Statements of Thiamine mononitrate (CAS NO.532-43-4): 22-24/25
S22: Do not breathe dust.
S24/25: Avoid contact with skin and eyes.

Specification

Synonyms of Thiamine mononitrate (CAS NO.532-43-4) are Stuartinic ; 3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methylthiazolium nitrate ; 3-(4-Amino-2-methylpyrimidyl-5-methyl)-4-methyl-5,beta-hydroxyethylthiazolium nitrate ; Aneurine mononitrate ; Aneurine nitrate ; Betabion mononitrate ; Thiamine nitrate ; Thiamine nitrate (salt) ; Thiazolium, 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methyl-, nitrate (salt) ; Vitamin B(sub 1) nitrate ; Vitamin B1 mononitrate ; Vitamin B1 nitrate ; Thiamine nitrate (salt) (8CI) ; Thiazolium, 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methyl-, nitrate (1:1) .