189955-89-3

Basic information

• Product Name: 3-hydroxy-5,5-dimethyl-4-[4-(methylsulfonyl)phenyl]furan-2(5H)-one
• Synonyms: 3-hydroxy-5,5-dimethyl-4-[4-(methylsulfonyl)phenyl]furan-2(5H)-one
• CAS NO: 189955-89-3
• Molecular Weight: 282.317
• Mol File: 189955-89-3.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 3-hydroxy-5,5-dimethyl-4-[4-(methylsulfonyl)phenyl]furan-2(5H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-hydroxy-5,5-dimethyl-4-[4-(methylsulfonyl)phenyl]furan-2(5H)-one(189955-89-3)
• EPA Substance Registry System: 3-hydroxy-5,5-dimethyl-4-[4-(methylsulfonyl)phenyl]furan-2(5H)-one(189955-89-3)

Safety Data

• Hazardous Substances Data: 189955-89-3(Hazardous Substances Data)

Upstream product

• 100-68-5 methyl-phenyl-thioether 
• 88324-55-4 2-bromo-2-methyl-1-[4-(methylsulfanyl)phenyl]propan-1-one 
• 102697-45-0 (4-methylsulfonylphenyl)-2-oxo-acetic acid ethyl ester 
• 62936-31-6 (4-methylsulfanylphenyl)oxoacetic acid ethyl ester 
• 300355-18-4 (4-methanesulfonyl-phenyl)-acetic acid methyl ester 
• 53207-59-3 2-methyl-1-[4-(methylsulfonyl)phenyl]propan-1-one 
• 49660-93-7 4'-bromoisobutyrophenone 
• 10342-83-3 4'-Bromopropiophenone 
• 180048-73-1 2-hydroxy-2-methyl-1-(4-(methylsulfonyl)-phenyl)propan-1-one 
• 13831-31-7 Acetoxyacetyl chloride 
• 108-88-3 toluene 
• 71867-98-6 2-hydroxy-2-methyl-1-(4-(methylthio)phenyl)-propan-1-one 
• 53207-58-2 2-methyl-1-(4-(methylthio)phenyl)-propan-1-one 

Downstream Products

• 213833-56-8 5,5-dimethyl-3-(2-methylallyloxy)-4-(4-methylsulfonylphenyl)-5H-furan-2-one 
• 213833-43-3 3-((2-hydroxy-2-methyl-3-butenyl)oxy)-5,5-dimethyl-4-(4-methylsulfonyl)phenyl-5H-furan-2-one 
• 189954-96-9 3-(Cyclopropylmethoxy)-5.5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5H-furan-2-one 
• 213833-44-4 3-(2-Bromo-1-methylethoxy)-5,5-dimethyl-4-(4-methylsulfonylphenyl)-5H-furan-2-one 
• 189954-76-5 3-(4-Methyl-5-nitro-2-pyridyloxy)-5,5-dimethyl-4-(4-methylsulfonyl)-phenyl-5H-furan-2-one 
• 189955-97-3 3-(3-Nitro-2-pyridyloxy)-5,5-dimethyl-4-(4-methyl-sulfonyl)phenyl-5H-furan-2-one 
• 213833-47-7 3-(((2R)-3-hydroxy-2-methylpropyl)oxy)-5,5-dimethyl-4-(4-methylsulfonylphenyl)-5H-furan-2-one 

Relevant articles and documents

Preparation method of ferocoxib

The invention relates to the technical field of medicines, in particular to a preparation method of ferocoxib. According to the preparation method, use of volatile heavy-odor raw material thioanisoleis avoided, and use of volatile high-corrosion heavy-odor isobutyryl chloride is avoided, so that environmental protection advantages are obvious; a hydroxyl compound is used for preparing a compoundwith a structure shown in a formula VI, so that use of liquid bromine with high volatility, high toxicity and high corrosivity can be avoided; a compound with a structure shown in a formula V, acetoxyacetyl chloride, an alkali and an organic solvent are mixed for carrying out an esterification reaction to obtain a compound with a structure shown in a formula VI, so that use of cyclopropoxy aceticacid which cannot be industrially produced on a scale is avoided, and then the process is easier to popularize. A test result shows that the preparation method of ferocoxib is more green and environmentally friendly, is more suitable for industrial popularization, and is far superior to the prior art.

NEW PROCESS FOR THE SYNTHESIS OF FIROCOXIB

The present invention concerns a process for the preparation of firocoxib, i.e. 3-(cyclopropylmethoxy)-5,5-dimethyl-4-(4-methylsulfonylphenyl)-furan-2-one, comprising steps (a)-(g), wherein the process provides for step (d) of the reaction of a new intermediate, i.e. 2-methyl-1-[4-(methylsulfanyl)phenyl]-1-oxopropan-2-yl (acetyloxy)acetate (compound VII) in the same organic solvent of step (a) in the presence of a catalyst and a phase transfer catalyst solution in the same organic solvent with hydrogen peroxide.

Synthesis methods of firocoxib and firocoxib intermediate

The invention relates to the field of medicine synthesis and provides synthesis methods of firocoxib and a firocoxib intermediate. The synthesis method of the firocoxib intermediate takes 4'-bromopropiophenone as a starting raw material and a condition th