53233-90-2Relevant articles and documents
Synthesis method of 2-(aminomethyl)-1, 3-thiazole-5-carboxylic acid methyl ester
-
Paragraph 0039-0043; 0049-0051; 0056-0058, (2022/01/20)
The invention discloses a synthetic method of 2-(aminomethyl)-1, 3-thiazole-5-carboxylic acid methyl ester, and belongs to the technical field of drug intermediate synthesis. According to the synthetic method, 2-methylthiazole-5-carboxylic acid is adopted as an initial raw material and sequentially subjected to classical chemical reactions of esterification, bromination, single reduction, bis-Boc amination and Boc removal to obtain the target compound 2-(aminomethyl)-1, 3-thiazole-5-carboxylic acid methyl ester, wherein the purity is 97% or above, the total yield reaches up to 48.3%, and the stability is good; the problems of low yield, difficulty in purification, large reagent smell, difficulty in obtaining of ring closing raw materials and difficulty in amplification of the whole process in synthesis of similar compounds in the prior art are solved, and application of the target compound in the field of medicines is promoted.
FLUOROALKYL-OXADIAZOLES AND USES THEREOF
-
Paragraph 00537-00539, (2021/06/26)
Provided herein are compounds identified as inhibitors of HDAC6 activity that can be used to treat various diseases and disorders.
Dihydropyrimidine Compounds and Their Uses in Preparation of Medicaments for Treating and Preventing Antiviral Diseases
-
Page/Page column 20, (2010/04/30)
The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt or hydrate thereof, to a process for preparing the compound of formula (I), and to use of the compound of formula (I) or a pharmaceutically acceptable salt or
DIHYDROPYRIMIDINE COMPOUNDS AND THEIR USES IN PREPARATION OF MEDICAMENTS FOR TREATING AND PREVENTING ANTIVIRAL DISEASES
-
Page/Page column 30, (2009/04/23)
The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt or hydrate thereof, to a process for preparing the compound of formula (I), and to use of the compound of formula (I) or a pharmaceutically acceptable salt or hydrate thereof as a medicament, in particular as a medicament for the treatment and prevention of type B hepatitis.