5325-43-9

Usage

Chemical Properties

white crystalline powder

Uses

Compound for preparation of "edisylate" salts

InChI:InChI=1/C2H6O6S2.2Na/c3-9(4,5)1-2-10(6,7)8;;/h1-2H2,(H,3,4,5)(H,6,7,8);;/q;2*+1/p-2

Upstream product

• 3018-09-5 1-chloro-2-bromoethylene 
• 7757-83-7 sodium sulfite 
• 74-86-2 acetylene 
• 106-93-4 ethylene dibromide 

Downstream Products

• 3118-70-5 Aethan-1,2-disulfonsaeure Calcium-Salz 
• 31469-08-6 ethane-1,2-disulfonyl chloride 
• 110-04-3 ethane-1,2-disulphonic acid 
• 74-86-2 acetylene 

Relevant academic research and scientific papers

A convenient synthesis of (E)-conjugated polyene sulfonyl derivatives with excellent stereospecificity

A highly selective synthesis of conjugated polyene sulfonyl derivatives is described via the elimination of disulfonyl chloride with readily accessible raw material dihaloalkane. The protocol offers a convenient way to form sulfonamides, sulfonates and even sulfones. Furthermore, this method was manipulated under mild condition with simple operation in high yield to afford only trans products.

Method for treating amyloidosis

Therapeutic compounds and methods for inhibiting amyloid deposition in a subject, whatever its clinical setting, are described. Amyloid deposition is inhibited by the administration to a subject of an effective amount of a therapeutic compound comprising an anionic group and a carrier molecule, or a pharmaceutically acceptable salt thereof, such that an interaction between an amyloidogenic protein and a basement membrane constituent is inhibited. Preferred anionic groups are sulfonates and sulfates. Preferred carrier molecules include carbohydrates, polymers, peptides, peptide derivatives, aliphatic groups, alicyclic groups, heterocyclic groups, aromatic groups and combinations thereof.

Short-chain aliphatic polysulfonates inhibit the entry of Plasmodium into red blood cells

Several steps in the pathogenesis of a Plasmodium falciparum infection depend on interactions of parasite surface proteins with negatively charged sugars on the surface of host cells such as sialate residues or glycosaminoglycans. For these reasons, our previous studies examining agents that interfere with heparan sulfate-protein binding during amyloidogenesis suggested that short-chain aliphatic polysulfonates may prove useful as antimalarial agents. A series of related polysulfonates were synthesized and assessed both in tissue culture with the asexual stages of P. falciparum in human red blood cells and in vivo by use of Plasmodium berghei infections in mice. Poly (vinylsulfonate sodium salt) (molecular weight range, 1,500 to 3,000) proved effective in interfering with P. falciparum merozoite entry into human red blood cells and significantly delaying the increase in the level of P. berghei parasitemia in mice. The concept that anionic molecules that mimic large polysaccharide structures may have antimalarial properties has been suggested and examined previously. Our results suggest that related anionic agents [poly (vinylsulfonate sodium salt)-like molecules] orders of magnitude smaller than those previously considered may prove useful in abrogating merozoite entry into erythrocytes and may potentially block sporozoite entry into liver cells. Structure-activity studies conducted to enhance these properties may provide compounds with scope for significant further analysis and development.

Method for treating amyloidosis

Therapeutic compounds and methods for inhibiting amyloid deposition in a subject, whatever its clinical setting, are described. Amyloid deposition is inhibited by the administration to a subject of an effective amount of a therapeutic compound comprising an anionic group and a carrier molecule, or a pharmaceutically acceptable salt thereof, such that an interaction between an amyloidogenic protein and a basement membrane constituent is inhibited. Preferred anionic groups are sulfonates and sulfates. Preferred carrier molecules include carbohydrates, polymers, peptides, peptide derivatives, aliphatic groups, alicyclic groups, heterocyclic groups, aromatic groups and combinations thereof.

Method for treating amyloidosis

Therapeutic compounds and methods for inhibiting amyloid deposition in a subject, whatever its clinical setting, are described. Amyloid deposition is inhibited by the administration to a subject of an effective amount of a therapeutic compound comprising an anionic group and a carrier molecule, or a pharmaceutically acceptable salt thereof, such that an interaction between an amyloidogenic protein and a basement membrane constituent is inhibited. Preferred anionic groups are sulfonates and sulfates. Preferred carrier molecules include carbohydrates, polymers, peptides, peptide derivatives, aliphatic groups, alicyclic groups, heterocyclic groups, aromatic groups and combinations thereof.

Method for treating amyloidosis

Therapeutic compounds and methods for inhibiting amyloid deposition in a subject, whatever its clinical setting, are described. Amyloid deposition is inhibited by the administration to a subject of an effective amount of a therapeutic compound comprising an anionic group and a carrier molecule, or a pharmaceutically acceptable salt thereof, such that an interaction between an amyloidogenic protein and a basement membrane constituent is inhibited. Preferred anionic groups are sulfonates and sulfates. Preferred carrier molecules include carbohydrates, polymers, peptides, peptide derivatives, aliphatic groups, alicyclic groups, heterocyclic groups, aromatic groups and combinations thereof.

1,2-Ethan-bis-sulfonylfluorid

The synthesis of 1,2-ethane-bissulfonyl fluoride is described. 1H and 19F NMR spectra are analysed and iterated.Novel NMR programs are commented upon. 1,2-Ethane-bis-sulfonyl fluoride favours a trans conformation. - Keywords: Synthesis; 1,2-Ethane-bis-sulfonyl fluoride; NMR spectroscopy; IR spectroscopy; Crystal structure; Mass spectrometry; NMR programs

Precise Conductimetric Studies on Aqueous Solutions of 2:2 Electrolytes. Part 3. - Detailed Study of Individual Electrolytes

This paper reports precise conductance values for dilute (-3) aqueous solution of twenty-three 2:2 salts at 25 deg C.Alkaline earth metal sulfates, thiosulphates, dithionates, tetrathionates, ethyl-, n-propyl-, n-butyl-disulphonates and acetylenedicarboxylates were studied.The results are analysed by means of the Lee-Wheathon conductance equation in terms of the limiting molar conductivity, Λ0, the association constant, KA, and the association distance, R.The interpretation of these parameters is discussed and the values compared with previous work on these and similar systems.