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5,7-dibromo-2-phenyl-1H-indole is a chemical compound characterized by its indole structure, which is a bicyclic aromatic system consisting of a benzene ring fused to a pyrrole. This particular compound is distinguished by the presence of two bromine atoms at the 5th and 7th positions of the indole ring, and a phenyl group attached at the 2nd position. The compound is often used in organic synthesis and as a building block in the creation of more complex molecules, particularly in pharmaceuticals and materials science. Its unique structure and functional groups make it a valuable intermediate in the synthesis of various indole-based derivatives, which can exhibit a range of biological activities and properties.

5326-35-2

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5326-35-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 5326-35-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,3,2 and 6 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 5326-35:
(6*5)+(5*3)+(4*2)+(3*6)+(2*3)+(1*5)=82
82 % 10 = 2
So 5326-35-2 is a valid CAS Registry Number.

5326-35-2Relevant academic research and scientific papers

Palladium-catalyzed tandem addition/cyclization in aqueous medium: Synthesis of 2-arylindoles

Yu, Shuling,Hu, Kun,Gong, Julin,Qi, Linjun,Zhu, Jianghe,Zhang, Yetong,Cheng, Tianxing,Chen, Jiuxi

, p. 4300 - 4307 (2017/07/10)

An efficient protocol to construct 2-arylindoles was developed through palladium-catalyzed tandem addition/cyclization of potassium aryltrifluoroborates with aliphatic nitriles in aqueous medium. The use of water as the reaction medium makes the synthesis process environmentally benign. A plausible mechanism for the formation of 2-arylindoles involving sequential nucleophilic addition followed by an intramolecular cyclization is proposed. Moreover, the utility of this catalytic tandem transformation was also demonstrated in an efficient gram-scale synthesis. This method provides an alternative synthetic tool for accessing a more diverse array of 2-arylindoles.

The Development of a Palladium-Catalyzed Tandem Addition/Cyclization for the Construction of Indole Skeletons

Yu, Shuling,Qi, Linjun,Hu, Kun,Gong, Julin,Cheng, Tianxing,Wang, Qingzong,Chen, Jiuxi,Wu, Huayue

, p. 3631 - 3638 (2017/04/11)

A palladium-catalyzed tandem addition/cyclization of 2-(2-aminoaryl)acetonitriles with arylboronic acids has been developed for the first time, achieving a new strategy for direct construction of indole skeletons. This system shows good functional group tolerance and remarkable chemoselectivity. In particular, the halogen (e.g., bromo and iodo) substituents are amenable to further synthetic elaborations thereby broadening the diversity of the products. Preliminary mechanistic experiments indicate that this transformation involves sequential nucleophilic addition followed by an intramolecular cyclization.

One-pot gold-catalyzed aminofluorination of unprotected 2-alkynylanilines

Arcadi, Antonio,Pietropaolo, Emanuela,Alvino, Antonello,Michelet, Véronique

supporting information, p. 2766 - 2769 (2013/07/19)

A tandem gold(I)-catalyzed aminocylization/fluorination and a two-step, one-pot gold(III)-catalyzed cyclization/electrophilic fluorination provide a convenient and general method for the synthesis of 3,3-difluoro-2-substituted- 3H-indoles in good yield un

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