5326-35-2Relevant articles and documents
Palladium-catalyzed tandem addition/cyclization in aqueous medium: Synthesis of 2-arylindoles
Yu, Shuling,Hu, Kun,Gong, Julin,Qi, Linjun,Zhu, Jianghe,Zhang, Yetong,Cheng, Tianxing,Chen, Jiuxi
, p. 4300 - 4307 (2017/07/10)
An efficient protocol to construct 2-arylindoles was developed through palladium-catalyzed tandem addition/cyclization of potassium aryltrifluoroborates with aliphatic nitriles in aqueous medium. The use of water as the reaction medium makes the synthesis process environmentally benign. A plausible mechanism for the formation of 2-arylindoles involving sequential nucleophilic addition followed by an intramolecular cyclization is proposed. Moreover, the utility of this catalytic tandem transformation was also demonstrated in an efficient gram-scale synthesis. This method provides an alternative synthetic tool for accessing a more diverse array of 2-arylindoles.
One-pot gold-catalyzed aminofluorination of unprotected 2-alkynylanilines
Arcadi, Antonio,Pietropaolo, Emanuela,Alvino, Antonello,Michelet, Véronique
supporting information, p. 2766 - 2769 (2013/07/19)
A tandem gold(I)-catalyzed aminocylization/fluorination and a two-step, one-pot gold(III)-catalyzed cyclization/electrophilic fluorination provide a convenient and general method for the synthesis of 3,3-difluoro-2-substituted- 3H-indoles in good yield un
