5326-44-3

Basic information

• Product Name: 2-(acetylamino)-5-iodobenzoic acid
• CAS NO: 5326-44-3
• Molecular Formula: C₉H₈INO₃
• Molecular Weight: 305.0692
• Mol File: 5326-44-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 475.3°C at 760 mmHg
• Flash Point: 241.3°C
• Density: 1.941g/cm³
• Vapor Pressure: 7.69E-10mmHg at 25°C
• Refractive Index: 1.694
• CAS DataBase Reference: 2-(acetylamino)-5-iodobenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(acetylamino)-5-iodobenzoic acid(5326-44-3)
• EPA Substance Registry System: 2-(acetylamino)-5-iodobenzoic acid(5326-44-3)

Safety Data

• Hazardous Substances Data: 5326-44-3(Hazardous Substances Data)

Usage

General Description

2-(acetylamino)-5-iodobenzoic acid is a compound with the molecular formula C9H8INO3. It contains a benzene ring with an amide group (NHCOCH3) attached at the 2-position and a carboxylic acid group (COOH) at the 5-position. It also has an iodine atom attached to the benzene ring. 2-(acetylamino)-5-iodobenzoic acid is commonly used as a reagent in organic synthesis and pharmaceutical research. Its properties and chemical structure make it useful in the production of various pharmaceuticals and as a building block in the synthesis of complex organic molecules. Additionally, its iodine atom can be used for radioimaging applications in medical diagnostics.

Upstream product

• 13194-68-8 4-iodo-2-methylaniline 
• 75-36-5 acetyl chloride 
• 5326-47-6 2-amino-5-iodobenzoic acid 
• 108-24-7 acetic anhydride 
• 117324-09-1 N-(4-iodo-2-methylphenyl)acetamide 

Downstream Products

• 4449-71-2 2-methyl-3-phenyl-6-iodoquinazolin-4(3H)-one 
• 5326-47-6 2-amino-5-iodobenzoic acid 
• 639465-98-8 5-Iodo-2-[(E)-(3-phenyl-acryloyl)amino]-benzoic acid 
• 639465-97-7 2-[(E)-3-(4-Hydroxy-3-methoxy-phenyl)-acryloylamino]-5-iodo-benzoic acid 
• 639465-99-9 2-[(E)-3-(4-Dimethylamino-phenyl)-acryloylamino]-5-iodo-benzoic acid 
• 40889-40-5 6-iodo-2-methylbenzo[d][1,3]oxazin-4-one 

Relevant articles and documents

An Improved and Efficient N-acetylation of Amines Using Choline Chloride Based Deep Eutectic Solvents

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Design and synthesis of quinazolinone tagged acridones as cytotoxic agents and their effects on EGFR tyrosine kinase

In a quest for finding potent cytotoxic molecules, we have designed and synthesized a new scaffold by tagging quinazolinones with an acridone moiety. The new acridone-4-carboximide derivatives were evaluated for their cytotoxic potentials against the MCF7 breast cancer cell line and three colon cancer cell lines (LS174T, SW1398, and WiDr). Compound 26 showed relatively potent cytotoxic activity among the derivatives, against all the cell lines tested. Mechanistic studies for the selected derivatives 7, 8, 16, 17, 25, and 26 were conducted through in vitro EGFR tyrosine kinase inhibition studies. The results indicate that compound 26 has a better EGFR tyrosine kinase inhibitory profile. The in vitro EGFR inhibition data was correlated with the cytotoxic properties, and molecular docking studies were performed with regard to the receptor autophosphorylation sites of the protein kinase domain of the EGFR.