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5326-80-7

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5326-80-7 Usage

Description

6-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine is an organic compound belonging to the pyrazolo[3,4-d]pyrimidin class, characterized by a molecular formula of C8H8N6 and a molar mass of 176.19 g/mol. As a derivative of pyrazolo[3,4-d]pyrimidine, it features an amine group, making it a valuable building block in pharmaceutical research and development for the synthesis of various bioactive compounds, particularly in medicinal chemistry. Its unique structure and properties also lend it potential applications in organic synthesis and chemical biology.

Uses

Used in Pharmaceutical Research and Development:
6-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine is utilized as a building block for the synthesis of bioactive compounds, playing a crucial role in the development of new pharmaceuticals. Its presence in the molecular structure can contribute to the desired biological activity and therapeutic effects of the resulting compounds.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 6-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine is employed for its potential to enhance the properties of drug candidates. Its incorporation into molecular structures can improve pharmacokinetics, potency, and selectivity, leading to more effective and safer medications.
Used in Organic Synthesis:
6-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine is also used in organic synthesis, where its unique structure allows for the creation of a variety of complex organic molecules. This can be particularly useful in the development of novel compounds with specific functions or properties.
Used in Chemical Biology:
Due to its distinctive structural features, 6-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine finds applications in chemical biology, where it can be used to study biological processes or to develop new tools for biological research, such as probes or inhibitors targeting specific biological pathways or enzymes.

Check Digit Verification of cas no

The CAS Registry Mumber 5326-80-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,3,2 and 6 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 5326-80:
(6*5)+(5*3)+(4*2)+(3*6)+(2*8)+(1*0)=87
87 % 10 = 7
So 5326-80-7 is a valid CAS Registry Number.
InChI:InChI=1/C6H7N5/c1-3-9-5(7)4-2-8-11-6(4)10-3/h2H,1H3,(H3,7,8,9,10,11)

5326-80-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine

1.2 Other means of identification

Product number -
Other names 4-Amino-2-methyl-pyrazolo<3,4-d>pyrimidin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:5326-80-7 SDS

5326-80-7Relevant articles and documents

Regioselective Synthesis of Pyrazolo[3,4-D[Pyrimidine Based Carbocyclic Nucleosides as Possible Antiviral Agent

Kasula, Mohan,Samunuri, Ramakrishnamraju,Chakravarty, Harapriya,Bal, Chandralata,Baba, Masanori,Jha, Ashok Kumar,Sharon, Ashoke

, p. 43 - 52 (2016)

Carbocyclic nucleosides are considered as nucleoside mimetic having high therapeutic potentials, however diverse exploration is still limited due to their synthetic difficulties. The major challenges are associated with the preparation of new base and carbocyclic sugar key intermediates. The modified base may provide conformational advantage to achieve better nucleoside mimetics and may also help in increasing the drug-like properties. In this manuscript, we report the use of acetamidine hydrochloride to synthesize 6-methyl-4-amino-pyrazolo[3,4-d]pyrimidine base and regioselective synthesis of six new carbocyclic nucleosides (6a-f) for antiviral evaluation. Theoretical investigations were carried out on the basis of thermodynamic and kinetic stability using MM based energy optimizations and QM based transition state search for the significant regioselectivity, which was further experimentally analyzed by NOE and UV spectroscopy.

1-PHENYLPYRROLIDIN-2-ONE DERIVATIVES AS PERK INHIBITORS

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Page/Page column 117, (2017/04/11)

The invention is directed to substituted pyrrolidinone and imidazolidinone derivatives. Specifically, the invention is directed to compounds according to Formula I: (I) wherein R1, R2, R3, R4, R5, R6, R7, X and Y are as defined herein. The compounds of the invention are inhibitors of PERK and can be useful in the treatment of cancer, pre-cancerous syndromes and diseases/injuries associated with activated unfolded protein response pathways, such as Alzheimer's disease, neuropathic pain, spinal cord injury, traumatic brain injury, ischemic stroke, stroke, Parkinson's disease, diabetes, metabolic syndrome, metabolic disorders, Huntington's disease, Creutzfeldt- Jakob Disease, fatal familial insomnia, Gerstmann-Str?ussler-Scheinker syndrome, and related prion diseases, amyotrophic lateral sclerosis, progressive supranuclear palsy, myocardial infarction, cardiovascular disease, inflammation, organ fibrosis, chronic and acute diseases of the liver, fatty liver disease, liver steatosis, liver fibrosis, chronic and acute diseases of the lung, lung fibrosis, chronic and acute diseases of the kidney, kidney fibrosis, chronic traumatic encephalopathy (CTE), neurodegeneration, dementias, frontotemporal dementias, tauopathies, Pick's disease, Neimann-Pick's disease, amyloidosis, cognitive impairment, atherosclerosis, ocular diseases, arrhythmias, in organ transplantation and in the transportation of organs for transplantation. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting PERK activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

PYRAZOLO-PYRIMIDINE DERIVATIVES AS ANTI-INFLAMMATORY AGENTS

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Page/Page column 31, (2008/06/13)

The present invention is directed to compounds of formula (I): a process for their preparation, to pharmaceutical compositions comprising the compounds and the preparation of said compositions, to intermediates and to use of the compounds for the manufacture of a medicament for therapeutic treatment, particularly for the treatment of inflammation and/or allergic conditions.

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