5327-00-4

Basic information

• Product Name: 2-bromo-N-ethyl-acetamide
• Synonyms: acetamide, 2-bromo-N-ethyl-;2-bromo-N-ethyl-ethanamide;2-bromo-N-ethylacetamide(SALTDATA: FREE);N-(Bromoacetyl)ethylamine, 2-Bromo-N-ethylethanamide;2-bromo-N-ethyl-acetamide
• CAS NO: 5327-00-4
• Molecular Formula: C₄H₈BrNO
• Molecular Weight: 166.02
• Mol File: 5327-00-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 271.3 °C at 760 mmHg
• Flash Point: 117.9 °C
• Appearance: /
• Density: 1.46 g/cm³
• Vapor Pressure: 0.00648mmHg at 25°C
• Refractive Index: 1.473
• CAS DataBase Reference: 2-bromo-N-ethyl-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-N-ethyl-acetamide(5327-00-4)
• EPA Substance Registry System: 2-bromo-N-ethyl-acetamide(5327-00-4)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 5327-00-4(Hazardous Substances Data)

Usage

General Description

2-Bromo-N-ethyl-acetamide is a chemical compound with the molecular formula C4H8BrNO. It falls under the category of organobromides and carboxamides. Its molecular weight is 182.018 g/mol. The compound appears as a clear, colorless liquid and has specific chemical and physical properties, most notably its boiling point, melting point, and density. It is an organic compound that contains a bromine atom, and its primary use can be found within the chemical industry where it is often utilized in a range of reactions to produce different chemical products. These products vary greatly based on the specific elements they are combined with. It should be handled with care as contact can cause skin and eye irritation.

InChI:InChI=1/C4H8BrNO/c1-2-6-4(7)3-5/h2-3H2,1H3,(H,6,7)

Upstream product

• 75-04-7 ethylamine 
• 598-21-0 2-Bromoacetyl bromide 
• 557-66-4 ethanamine hydrochloride 

Downstream Products

• 57837-08-8 2-(2,6-Diethyl-phenylamino)-N-ethyl-acetamide 
• 1020717-43-4 AGN 211334 
• 1207634-91-0 N-ethyl-2-[6-(3-fluoro-4-methoxybenzyl)-1-oxo-1,2,4,7-tetrahydro-3H-indolo[2,3-c][1,7]naphthyridin-3-yl]acetamide 
• 1207634-49-8 N-ethyl-2-[6-(3-fluoro-4-methoxybenzyl)-1,2,4,7-tetrahydro-3H-indolo[2,3-c][1,7]naphthyridin-3-yl]acetamide 
• 1021089-21-3 N-ethyl-2-[(4-methoxyphenyl)amino]acetamide 
• 333963-35-2 2-{[6-Amino-3,5-dicyano-4-(4-hydroxyphenyl)-2-pyridinyl]sulfanyl}-N-ethylacetamide 
• 188727-02-8 2'-(4-mercapto-1-phenylpyrazolo[3,4-d]pyrimidin-6-ylthio)-N-ethyl-ethanamide 

Relevant articles and documents

Development of Membrane-Active Honokiol/Magnolol Amphiphiles as Potent Antibacterial Agents against Methicillin-Resistant Staphylococcus aureus (MRSA)

Currently, infections caused by drug-resistant bacteria have become a new challenge in anti-infective treatment, seriously endangering public health. In our continuous effort to develop new antimicrobials, a series of novel honokiol/magnolol amphiphiles were prepared by mimicking the chemical structures and antibacterial properties of cationic antimicrobial peptides. Among them, compound 5i showed excellent antibacterial activity against Gram-positive bacteria and clinical MRSA isolates (minimum inhibitory concentrations (MICs) = 0.5-2 μg/mL) with low hemolytic and cytotoxic activities and high membrane selectivity. Moreover, 5i exhibited rapid bactericidal properties, low resistance frequency, and good capabilities of disrupting bacterial biofilms. Mechanism studies revealed that 5i destroyed bacterial cell membranes, resulting in bacterial death. Additionally, 5i displayed high biosafety and potent in vivo anti-infective potency in a murine sepsis model. Our study indicates that these honokiol/magnolol amphiphiles shed light on developing novel antibacterial agents, and 5i is a potential antibacterial candidate for combating MRSA infections.

Optimized synthesis and indium complex formation with the bifunctional chelator NODIA-Me

The bifunctional chelator NODIA-Me holds promise for radiopharmaceutical development. NODIA-Me is based on the macrocycle TACN (1,4,7-triazacyclononane) and incorporates two additional methylimidazole arms for metal chelation and an acetic acid residue fo

Functionalizing glycine derivatives by direct C-C bond formation

(Chemical Equation Presented) Come on glycine: Two different types of glycine derivatives are α-functionalized using cross-dehydrogenative- coupling (CDC) reactions. The method allows the efficient attachment of a malonate or aromatic alkyne group on the α-position of the glycine derivatives under very mild conditions.