5331-70-4

Basic information

• Product Name: diethyl but-3-en-1-yl(methyl)propanedioate
• CAS NO: 5331-70-4
• Molecular Formula: C₁₂H₂₀O₄
• Molecular Weight: 228.2848
• Mol File: 5331-70-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 281°C at 760 mmHg
• Flash Point: 128.3°C
• Density: 0.998g/cm³
• Vapor Pressure: 0.00366mmHg at 25°C
• Refractive Index: 1.445
• CAS DataBase Reference: diethyl but-3-en-1-yl(methyl)propanedioate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl but-3-en-1-yl(methyl)propanedioate(5331-70-4)
• EPA Substance Registry System: diethyl but-3-en-1-yl(methyl)propanedioate(5331-70-4)

Safety Data

• Hazardous Substances Data: 5331-70-4(Hazardous Substances Data)

Upstream product

• 31696-00-1 diethyl 2-(3-butenyl)malonate 
• 74-88-4 methyl iodide 
• 110-52-1 1,4-dibromo-butane 
• 64-17-5 ethanol 
• 609-08-5 Diethyl methylmalonate 
• 105-53-3 diethyl malonate 
• 778-29-0 but-3-enyl 4-methylbenzenesulfonate 
• 62116-54-5 sodium diethyl methylmalonate 
• 5162-44-7 1-bromo-4-butene 
• 50-00-0 formaldehyd 
• 107-05-1 3-chloroprop-1-ene 

Relevant articles and documents

Stereocontrolled Construction of the A-Ring of Nitiol Using a Pauson-Khand Cycloaddition-Ring Fragmentation Strategy

(matrix presented) A stereocontrolled construction of the A-ring of nitiol (1) is presented. Key features in this approach are a diastereoselective Pauson-Khand cycloaddition and a Norrish type 1 fragmentation reaction.

PYRIMIDINE AND PYRIDINE DERIVATIVES AND USE IN TREATMENT, AMELIORATION OR PREVENTION OF INFLUENZA THEREOF

Provided herein is a compound of formula (I), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, prodrug, codrug, cocrystal, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, which is useful in treating, ameliorating or preventing influenza.

Reactions of Methyl-Substituted Hex-5-enyl and Pent-4-enyl Radicals

Relative and absolute kinetic data have been determined for ring closure of methyl-substituted hex-5-enyl radicals: 2-methyl-(10a), 3-methyl-(4a), 4-methyl-(5a), 2,2-dimethyl-(10c), 3,3-dimethyl-(4c) and 4,4-dimethyl-hex-5-enyl (5c) radicals, generated by interaction of tributylstannane with the corresponding bromides (1a)-(3a) and (1c)-(3c).Each radical undergoes regiospecific or highly regioselective 1,5-cyclization more rapidly than does the unsubstituted radical (4d).The rate enhancements, which arise mainly from lowering of the activation energy, can be rationalized in terms of the gem-dimethyl effect. 1,5-Ring closures of monosubstituted species are stereoselective: 2-methyl- and 4-methyl-hex-5-enyl radicals (10a) and (5a) give mainly trans products, whereas 3-methylhex-4-enyl radical gives mainly the cis.This behaviour reflects the effect of the substituent on the stabilities of cyclic transition complexes in chair-like conformations.Ring closure of 2,2-dimethylpent-4-enyl radical or of 3,3-dimethylpent-4-enyl radical (19) could not be detected.