ethyl 3,3-dimethyl-2-oxobutanoate

Base Information

• Chemical Name: ethyl 3,3-dimethyl-2-oxobutanoate
• CAS No.: 5333-74-4
• Molecular Formula: C8H14O3
• Molecular Weight: 158.197
• Hs Code.: 2918300090
• Mol file: 5333-74-4.mol

Synonyms:trimethylethyl pyruvate;ETHYL 3,3-DIMETHYL-2-OXO-BUTANOATE;ethyl 3,3-dimethyl-2-oxo-butyrate;3,3-dimethyl-2-oxo-butyric acid ethyl ester;trimethylpyruvic acid ethylester;

Chemical Property of ethyl 3,3-dimethyl-2-oxobutanoate

Chemical Property:

• Vapor Pressure: 0.353mmHg at 25°C
• Boiling Point: 198.8°C at 760 mmHg
• Flash Point: 73°C
• PSA: 43.37000
• Density: 0.981g/cm³
• LogP: 1.16470

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 3,3-dimethyl-2-oxobutanoate

There total 8 articles about ethyl 3,3-dimethyl-2-oxobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

ethyl bromide (74-96-4) + trimethylpyruvic acid (815-17-8) → ethyl 3,3-dimethyl-2-oxobutanoate (5333-74-4)

Guidance literature:

With tert-butyl methyl ether; 1,8-diazabicyclo[5.4.0]undec-7-ene; at 38 ℃; for 23h;

DOI:10.1021/jo035794p

Reference yield: 96.0%

tert-butylmagnesium chloride (677-22-5) + oxalic acid diethyl ester (95-92-1) → ethyl 3,3-dimethyl-2-oxobutanoate (5333-74-4)

Guidance literature:

tert-butylmagnesium chloride; oxalic acid diethyl ester; In tetrahydrofuran; toluene; at -78 ℃; for 16h; Inert atmosphere; Schlenk technique;

With hydrogenchloride; In tetrahydrofuran; water; toluene; at -78 - 20 ℃; Inert atmosphere; Schlenk technique;

DOI:10.1016/j.poly.2016.10.021

Reference yield: 49.0%

carbon monoxide (201230-82-2) + tert.-butyl lithium (594-19-4) + Diethyl carbonate (105-58-8,76619-83-5) → ethyl 3,3-dimethyl-2-oxobutanoate (5333-74-4)

Guidance literature:

In tetrahydrofuran; diethyl ether; pentane; a) -110 deg C, 2 h, b) to r.t.;

DOI:10.1021/jo00020a014

upstream raw materials:

3,3-dimethyl-2-oxo-butyraldehyde diethylacetal

tert-butylmagnesium chloride

oxalic acid diethyl ester

ethanol

Downstream raw materials:

trimethylpyruvic acid

Hexamethyldisiloxane

3,3-Dimethyl-2-[(Z)-trimethylsilanyl-imino]-butyric acid ethyl ester

(R)-3,3-dimethylbutane-1,2-diol