53332-64-2

Usage

Physical appearance

Colorless to light yellow liquid
The compound appears as a transparent or slightly colored liquid.

Odor

Pungent
It has a strong, irritating smell that can be detected at low concentrations.

Usage in organic synthesis

Building block for pharmaceuticals, agrochemicals, and fine chemicals
The compound serves as a starting material or intermediate in the synthesis of various chemical products, including medications, pesticides, and other specialty chemicals.
5. Raw material for production of rubber chemicals, dyes, and fragrances
1-isopropyl-1H-imidazole-2-carbaldehyde is used as a key ingredient in the manufacturing of chemicals used in rubber, dye, and fragrance industries.

Potential applications in materials science

Research and development of new materials
The compound may be utilized in the creation and study of innovative materials with unique properties and applications.

Research tool in chemical and biochemical studies

Facilitates understanding of chemical reactions and processes
As a versatile compound, 1-isopropyl-1H-imidazole-2-carbaldehyde can be employed in various research projects to investigate chemical and biochemical phenomena.

Upstream product

• 75-26-3 isopropyl bromide 
• 10111-08-7 2-imidazolecarbaldehyde 
• 68-12-2 N,N-dimethyl-formamide 
• 4532-96-1 1-isopropyllimidazole 
• 75-30-9 2-iodo-propane 

Downstream Products

• 1578301-14-0 (2E,6E)-2,6-bis((1-isopropyl-1H-imidazole-2-yl)methylene)cyclohexanone 
• 497850-17-6 7-{4-[2-(butoxy)ethoxy]phenyl}-1-isobutyl-N-({4-[(1-isopropyl-1H-imidazol-2-yl)methyl]sulfanyl}phenyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide 
• 497851-79-3 4-{[(1-isopropyl-1H-imidazol-5-yl)methyl]sulfanyl}aniline 
• 135205-82-2 (1-isopropyl-1H-imidazol-2-yl)methanol 

Relevant academic research and scientific papers

CYCLIC AMINE DERIVATIVE AS AGENT FOR PROMOTING ADVILLIN FUNCTION, AND NOVEL CYCLIC AMINE DERIVATIVE AND PHARMACEUTICAL USE THEREOF

An object of the present invention is to provide an agent for promoting advillin function that comprises a low molecular weight compound, and is useful for treatment of axonal injury. The present invention provides an agent for promoting advillin function, comprising a cyclic amine derivative typically represented by the following chemical formula, or a pharmacologically acceptable salt thereof as an active ingredient.

CYCLIC AMINE DERIVATIVE AND PHARMACEUTICAL USE THEREOF

An object of the present invention is to provide a compound exerting an analgesic effect against pain, in particular, neuropathic pain and/or fibromyalgia syndrome. The present invention provides a cyclic amine derivative represented by the following general formula, or a pharmacologically acceptable salt thereof.

CYCLIC AMINE DERIVATIVE AND PHARMACEUTICAL USE THEREOF

A cyclic amine derivative represented by a general formula (I) or a pharmacologically acceptable salt thereof: wherein n represents 1 or 3, R1 represents an alkyl group having 1 to 6 carbon atoms unsubstituted, substituted with a halogen atom or substituted with an alkyloxy group having 1 to 4 carbon atoms and R2 represents a hydrogen atom or a halogen atom.

Design, synthesis, and evaluation of novel heteroaromatic analogs of curcumin as anti-cancer agents

To improve the potential of curcumin to treat advanced hormone-refractory prostate cancer, three series (A-C) of heteroaromatic analogs (thirty two compounds) with different monoketone linkers have been synthesized and evaluated for cytotoxicity against two human androgen-independent prostate cancer cell lines (PC-3 and DU-145). Among them, thirty analogs are more potent than curcumin against PC-3 cells, and twenty one analogs are more cytotoxic towards DU-145 cells relative to curcumin. The most potent compounds (44, 45, 51, and 52) also showed impressive cytotoxicity against three other metastatic cancer cell lines (MDA-MB-231, HeLa, and A549), with IC50 values ranging from 50 nM to 390 nM. All four most potent analogs exhibited no apparent cytotoxicity towards the MCF-10A normal mammary epithelial cells. Taken together, selective enhancement of cell death in prostate cancer cell lines and other aggressive cancer cell lines suggests that nitrogen-containing heteroaromatic rings are promising bioisosteres of the substituted phenyl ring in curcumin. Published by Elsevier Masson SAS.

Selection of chiral zinc catalysts for the kinetic resolution of esters via dynamic templating

Dynamic combinatorial libraries of chiral tetradentate bis-imine zinc(II) complexes have been prepared and screened for (1) their discrimination of enantiomeric picolinate esters and pyridyl phosphonate transition state analogs (TSAs) and (2) their cataly

BETA CARBOLINES AND USES THEREOF

This invention provides beta-carboline compounds of formula I: wherein R1, R2, R3, R4, R5, G, and x are as described in the specification. The compounds are useful for treating cancer and inflammatory disorders.

Orally active CCR5 antagonists as anti-HIV-1 agents. Part 3: Synthesis and biological activities of 1-benzazepine derivatives containing a sulfoxide moiety

In order to develop orally active CCR5 antagonists, 1-propyl- or 1-isobutyl-1-benzazepine derivatives containing a sulfoxide moiety have been designed, synthesized, and evaluated for their biological activities. Sulfoxide compounds containing a 2-pyridyl

BENZAZEPINE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE

The present invention provides a novel benzazepine derivative represented by formula : wherein, R1 is a 5- or 6-membered aromatic ring, R2 is lower alkyl group, etc., Y is an optionally substituted imino group, ring A and ring B are independently an optionally substituted aromatic ring, W is formula -W1-X2-W2- (W1 and W2 are independently S(O)m1 (m1 is 0, 1 or 2), etc., and X2 is an optionally substituted alkylene groupetc. ), a preparation method and use thereof.

Chemokine receptor binding heterocyclic compounds with enhanced efficacy

The invention relates to heterocyclic compounds consisting of a core nitrogen atom surrounded by three pendant groups, wherein two of the three pendant groups are preferably benzimidazolyl methyl and tetrahydroquinolyl, and the third pendant group contains N and optionally contains additional rings. The compounds bind to chemokine receptors, including CXCR4 and CCR5, and demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).