5335-29-5

Basic information

• Product Name: 3-CHLORO-4-PHENOXYANILINE
• Synonyms: AKOS B021984;3-CHLORO-4-PHENOXYANILINE;CHEMBRDG-BB 4012411;ART-CHEM-BB B021984;[3-chloro-4-(phenoxy)phenyl]amine;3-Chloro-4-phenoxyaniline ,97%;(3-chloro-4-phenoxyphenyl)amine(SALTDATA: HCl);3-chloro-4-phenoxyaniline HCl
• CAS NO: 5335-29-5
• Molecular Formula: C₁₂H₁₀ClNO
• Molecular Weight: 219.67
• Mol File: 5335-29-5.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 335.9°Cat760mmHg
• Flash Point: 156.9°C
• Appearance: /
• Density: 1.26g/cm³
• Vapor Pressure: 0.000116mmHg at 25°C
• Refractive Index: 1.627
• CAS DataBase Reference: 3-CHLORO-4-PHENOXYANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-4-PHENOXYANILINE(5335-29-5)
• EPA Substance Registry System: 3-CHLORO-4-PHENOXYANILINE(5335-29-5)

Safety Data

• Hazardous Substances Data: 5335-29-5(Hazardous Substances Data)

Usage

General Description

3-Chloro-4-phenoxyaniline is a chemical compound that consists of a chlorine atom, a phenyl group, and an aniline group. It is commonly used in the production of pesticides and herbicides, particularly in the synthesis of plant growth regulators. Due to its potential toxicity and environmental impact, it is important to handle and dispose of this chemical with care and in accordance with safety regulations. It is also important to consider the potential health risks associated with exposure to 3-chloro-4-phenoxyaniline and to use appropriate safety equipment when working with this compound.

InChI:InChI=1/C12H10ClNO/c13-11-8-9(14)6-7-12(11)15-10-4-2-1-3-5-10/h1-8H,14H2

Upstream product

• 56966-69-9 2-chloro-4-nitro-1-phenoxy-benzene 
• 350-30-1 3-chloro-4-fluoronitrobenzene 
• 7439-89-6 iron 
• 108-95-2 phenol 
• 29682-39-1 1-bromo-2-chloro-4-nitrobenzene 

Downstream Products

• 1314114-53-8 3,5-dichloro-N-(3-chloro-4-phenoxyphenyl)-2-hydroxybenzamide 
• 77859-28-0 1-(3-Chloro-4-phenoxyphenyl)thiourea 
• 1430796-83-0 2-chloro-4-isothiocyanato-1-phenoxybenzene 
• 1620782-53-7 N³-(3-chloro-4-phenoxyphenyl)-1H-[1,2,4]triazole-3,5-diamine 
• 1620878-52-5 (Z)-methyl N-3-chloro-4-phenoxyphenyl-N'-cyanocarbamimidothioate 
• 1221878-77-8 (S)-2-(2-(1H-imidazol-5-yl)acetamido)-3-(benzyloxy)-N-(3-chloro-4-phenoxyphenyl)propanamide 
• 1222196-45-3 (S)-2-amino-3-benzyloxy-N-(3-chloro-4-phenoxyphenyl)propanamide 
• 1346176-03-1 N-(3-chloro-4-phenoxyphenyl)-5H-pyrrolo[3,2-d]pyrimidin-4-amine 
• 56966-69-9 2-chloro-4-nitro-1-phenoxy-benzene 
• 179687-18-4 4-(3-chloro-4-phenoxyanilino)-6,7-dimethoxyquinazoline hydrochloride salt 

Relevant articles and documents

Structural Development of Salicylanilide-Based SPAK Inhibitors as Candidate Antihypertensive Agents

Hypertension is an important target for drug discovery. We have focused on the with-no-lysine kinase (WNK)-oxidative stress-responsive 1 (OSR1) and STE20/SPS1-related proline-alanine-rich protein kinase (SPAK)-NaCl cotransporter (NCC) signal cascade as a potential target, and we previously developed a screening system for inhibitors of WNK-OSR1/SPAK-NCC signaling. Herein we used this system to examine the structure-activity relationship (SAR) of salicylanilide derivatives as SPAK kinase inhibitors. Structural design and development based on our previous hit compound, aryloxybenzanilide derivative 2, and the veterinary anthelmintic closantel (3) led to the discovery of compound 10 a as a potent SPAK inhibitor with reduced toxicity. Compound 10 a decreased the phosphorylation level of NCC in mouse kidney in vivo, and appears to be a promising lead compound for a new class of antihypertensive drugs.

Structural development of N-(4-phenoxyphenyl)benzamide derivatives as novel SPAK inhibitors blocking WNK kinase signaling

We report here structural development of N-(4-phenoxyphenyl)benzamide derivatives as novel SPAK (STE20/SPS1-related proline/alanine-rich kinase) inhibitors. Abnormal activation of the signal cascade of with-no-lysine kinase (WNK) with OSR1 (oxidative stress-responsive kinase 1)/SPAK and NCC (NaCl cotransporter) results in characteristic salt-sensitive hypertension, and therefore inhibitors of the WNK-OSR1/SPAK-NCC cascade are candidates for antihypertensive drugs. Based on the structure of lead compound 2, we examined the SAR of N-(4-phenoxyphenyl)benzamide derivatives, and developed compound 20l as a potent SPAK inhibitor. Compounds 20l is a promising candidate for a new class of antihypertensive drugs.

AGRICULTURAL CHEMICALS

The present invention relates to picolinic acid derivatives that are useful in treating fungal diseases ofplants.