5336-17-4

Usage

Uses

Used in Chemical Research and Development:
N-Ethyliminodiacetic acid is utilized as a reagent in chemical research and development for its ability to participate in various chemical reactions. Its reactive nature allows it to be a key component in the synthesis of new compounds and the study of chemical processes.
Used in Industrial Chemical Processes:
In the industrial sector, N-Ethyliminodiacetic acid is employed as a catalyst or intermediate in the production of various chemical products. Its versatility in chemical reactions makes it a valuable asset in the synthesis of specialty chemicals and pharmaceuticals.
Used in Environmental Monitoring:
Given its potential for long-term environmental damage, N-Ethyliminodiacetic acid is also used in environmental monitoring programs to assess and control its release into aquatic ecosystems, ensuring compliance with environmental regulations and minimizing ecological impact.
Used in Safety and Hazard Management:
N-Ethyliminodiacetic acid is used in the development of safety protocols and hazard management strategies within chemical laboratories and industries. Its inclusion in these programs helps to ensure the safe handling, storage, and disposal of the compound, reducing the risk of accidents and environmental contamination.

Upstream product

• 75-07-0 acetaldehyde 
• 142-73-4 iminodiacetic acid 
• 91017-42-4 ethylimino-di-acetic acid diethyl ester 
• 75-03-6 ethyl iodide 
• 75-04-7 ethylamine 
• 79-11-8 chloroacetic acid 
• 50-00-0 formaldehyd 
• 143-33-9 sodium cyanide 

Relevant academic research and scientific papers

Synthesis and structure revision of dimeric tadalafil analogue adulterants in dietary supplements

A number of phosphodiesterase 5 (PDE5) inhibitors approved by authorities have been used successfully in the treatment of erectile dysfunction. These medicines must be prescribed carefully due to their adverse effects, but they and their analogues are being illegally added to dietary supplements. These illegal dietary supplements pose a significant risk to public health. Several dimeric tadalafil analogues have been synthesized for use as reference standards in the inspection of functional foods that are mainly advertised as sexual enhancement products. During the course of this synthesis, 1-[bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate (HATU) was proven to be the reagent of choice for amide coupling to produce these dimeric tadalafil analogues. Moreover, the trans-isomer structures tentatively assigned for the isolated dimeric tadalafil analogues (bisprehomotadalafil and bisprecyclopentyltadalafil) found in dietary supplements are now revised to cis-isomer structures.

Efficient and Scalable Synthesis of Glucokinase Activator with a Chiral Thiophenyl-Pyrrolidine Scaffold

Herein we describe the practical synthesis of a potent glucokinase activator (1) that has a chiral thiophenyl-pyrrolidine scaffold. The key to the successful synthesis was the application of a telescoped chiral-pool synthesis from a commercially available l-proline methyl ester derivative to introduce the chirality of the thiophenyl-pyrrolidine moiety. This second-generation synthesis of 1 provided several advantages over the previous method including an operational simplicity and avoidance of purification by column chromatography. The industrial relevance of this synthetic method in large-scale preparation was demonstrated by the production of 54.6 kg of 1 with an excellent chemical and optical purity.