53369-76-9

Usage

Member of the benzonitrile class of compounds

This means that the compound is part of a larger group of similar compounds that are commonly used in the production of pharmaceuticals, dyes, and other industrial chemicals.

Derivative of benzonitrile with a dimethylaminomethyl group attached to the benzene ring

This describes the specific structure of the compound, which is based on a benzonitrile molecule with a dimethylaminomethyl group added to it.

Commonly used as a reagent in organic synthesis

This means that the compound is often used in chemical reactions to help produce other compounds.

Building block for the production of other complex organic compounds

This indicates that the compound is a key ingredient in the creation of more complex organic molecules.

Suitable for a wide range of applications in the chemical and pharmaceutical industries

This means that the compound has a variety of uses in different areas of these industries, thanks to its unique structure and properties.

InChI:InChI=1/C10H12N2/c1-12(2)8-10-6-4-3-5-9(10)7-11/h3-6H,8H2,1-2H3/p+1

Upstream product

• 124-40-3 dimethyl amine 
• 22115-41-9 2-(bromomethyl)benzonitrile 
• 10442-39-4 tetra-n-butylammonium cyanide 
• 38710-51-9 2-methyl-phthalazinium; iodide 
• 36438-99-0 1,2-dihydro-2-methylphthalazine 
• 253-52-1 PHTHALAZINE 
• 94408-70-5 2,2-dimethyl-1,2-dihydrophthalazinium iodide 

Downstream Products

• 53369-77-0 1-[2-(aminomethyl)phenyl]-N,N-dimethylmethanamine 
• 55741-01-0 o-N,N-dimethylaminomethylbenzoic acid 
• 135277-12-2 2-Dimethylaminomethyl-benzamid 
• 1004759-76-5 N-(2'-cyanobenzyl)-N,N-dimethyl-N-[(-)-8-phenylmenthoyloxycarbonylmethyl]ammonium bromide 
• 19886-78-3 1-formyl-2-[(dimethylamino)methyl]benzene 

Relevant academic research and scientific papers

Asymmetric Sommelet-Hauser rearrangement of N-benzylic ammonium salts

(Chemical Equation Presented) [2,3] over [1,2]: The asymmetric Sommelet-Hauser rearrangement of an ammonium salt derived from N-benzylic proline-derived or N-benzylic glycine (-)-8-phenylmenthol ester is shown to proceed with remarkably high levels of stereoselectivity. The method provides unique and efficient access to optically active α-aryl amino acid derivatives.

HYDRAZONE DERIVATIVE

A compound represented by the following formula (I): wherein R1 represents hydrogen, aryl which may have a substituent, a saturated or unsaturated 5- to 7-membered heterocyclic group which may have a substituent, etc.; R2 represents hydrogen, aryl which may have a substituent, a saturated or unsaturated 5- to 7-membered heterocyclic group which may have a substituent, etc.; R3 represents hydrogen, etc.; Ar represents a divalent group derived from aromatic hydrocarbon, etc.; X represents a single bond, linear or branched alkylene having from 1 to 3 carbon atoms which may have a substituent, etc.; and G represents halogen, a saturated or unsaturated 5- or 6-membered cyclic hydrocarbon group which may have a substituent, a saturated or unsaturated 5- to 7-membered heterocyclic group which may have a substituent, etc., a salt thereof or a solvate thereof; and an agent for inhibiting aggregation and/or deposition of an amyloid protein or an amyloid-like protein, which comprises the compound, a salt thereof or a solvate thereof

15N and 13C NMR studies on cyclopalladated complexes. Synthetic palladium cyanide chemistry leading to organic nitriles

15N NMR spectroscopy has been used to determine whether the 15NO group is coordinated in the cyclopalladated nitrosoamine complex 2, PdCl and K2, 11, as well as in several platinum

Elimination Reactions of Hydrazonium Salts: Experimental and Theoretical Evidence for a Large Stereoelectronic Effect of Nitrogen

Elimination of trimethylamine from hydrazonium salts (8, R = Me) is promoted by base (methoxide ion in methanol).The mechanism is characterized as E2 as shown by substituent effects (ρ = +2.57), Broensted coefficients, a primary kinetic isotope effect (kH/kD = 2.10), and solvent effects.Variation in the leaving group (8, R = arylmethyl) shows that N-N bond cleavage is less well advanced in the transition state than C-H bond breaking.The elimination to give the nitrile is syn-periplanar and, using the phthalazinium salt 4 as a model for the anti elimination, an anti/syn ratio of ca. 102 is found.The reactions have been modelled using ab initio methods with the transition structures located at the HF/3-21G level and relative energies computed using the MP2/6-31G* method.Using both H2O and NH3 as model bases to induce elimination on +, the calculated energy for anti elimination is lower (in the range 11-13 kcal mol-1) than that for syn elimination.The implications of the results for the ease of formation of nitriles from aldehydes via the hydrazonium salt route are discussed.