53427-97-7

Usage

Uses

Used in Pharmaceutical Industry:
1-(4-NITRO-PHENYL)-1H-PYRIDIN-2-ONE is used as a key intermediate in the synthesis of various pharmaceutical compounds for its ability to participate in multiple chemical reactions, contributing to the development of new drugs and bioactive molecules.
Used in Research Applications:
In the research field, 1-(4-NITRO-PHENYL)-1H-PYRIDIN-2-ONE serves as a valuable chemical entity for studying the properties and behavior of pyridine derivatives, as well as exploring its potential in the creation of novel chemical compounds and materials.

InChI:InChI=1/C11H8N2O3/c14-11-3-1-2-8-12(11)9-4-6-10(7-5-9)13(15)16/h1-8H

Upstream product

• 3902-84-9 potassium 2-oxo-2H-pyridin-1-ide 
• 100-00-5 4-chlorobenzonitrile 
• 636-98-6 p-nitrobenzene iodide 
• 142-08-5 2-Pyridone 
• 586-78-7 para-nitrophenyl bromide 
• 142-08-5 2-hydroxypyridin 
• 350-46-9 4-Fluoronitrobenzene 

Downstream Products

• 103983-87-5 1-(p-Nitrophenyl)-2-thiopyridon 
• 111015-93-1 1-(4-nitrophenyl)-3,5-dinitro-2-pyridone 
• 13663-59-7 N-(4-nitrophenyl)cyclohexylamine 
• 13143-47-0 1-(4-aminophenyl)pyridin-2(1H)-one 
• 438056-68-9 1-(4-aminophenyl)piperidine-2-one 

Relevant academic research and scientific papers

C(sp2)-H Trifluoromethylation of enamides using TMSCF3: Access to trifluoromethylated isoindolinones, isoquinolinones, 2-pyridinones and other heterocycles

A method for the direct C(sp2)-H trifluoromethylation of enamides, including biologically relevant isoindolinones, isoquinolinones and 2-pyridinones using TMSCF3 under oxidative conditions is presented. The protocol is convenient, operationally simple and exhibits high tolerance across a multitude of relevant handles and functional groups.

ANTIVIRAL COMPOUNDS

The present invention discloses compounds of Formula (I): wherein the variables in Formula (I) are defined as described herein. Also disclosed are pharmaceutical compositions containing such compounds and methods for using the compounds of Formula (I) in the prevention or treatment of HCV infection.

NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE

The present invention relates to piperazine derivatives that act as inhibitors of stearoyl-CoA desaturase. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.

Tetrabutylammonium pyridin-2-olate: A new reagent for the efficient synthesis of N-aryl pyridin-2-ones

A new reagent, tetrabutylammonium pyridin-2-olate, was prepared and its application to the efficient synthesis of N-aryl pyridine-2-ones was demonstrated using CuI-catalyzed coupling reactions with aryl iodides. This coupling reaction is mild, high-yielding, and remarkably chemoselective (N- vs. O-arylation). It is also compatible with substrates containing labile functional groups. Georg Thieme Verlag Stuttgart.

Preparation of N-aryl pyridones

A novel process and intermediates thereof for making N-aryl pyridones of the type shown below from appropriate pyridinolates is described. These compounds are useful as intermediates for the synthesis of clinical candidates.

PROLINE DERIVATIVES

The invention relates to novel compounds of formula (I), wherein X, Y, R1, R2, R3, R4 and n have the meaning cited in claim 1, are inhibitors of the coagulation factor Xa and can be used for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours.

TETRAHYDROISOQUINOLINES AS FACTOR XA INHIBITORS

The present invention is directed to compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof which are inhibitors of Factor Xa. The present invention is also directed to and intermediates used in making such compounds, pharmaceutical compositions containing such compounds, methods to prevent or treat a number of conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.

A versatile copper-catalyzed coupling reaction of pyridin-2(1H)-ones with aryl halides

A robust method has been developed to couple a wide variety of pyridin-2-ones and aryl halides. This C-N bond forming reaction makes use of catalytic copper(I) iodide and the ligand 8-hydroxyquinoline. These conditions tolerate a wide degree of functional

Compositions and methods for treatment of epilepsy

A method of treating a mammal with an epileptic condition, comprising: administering to said mammal a pharmaceutical composition containing an effective amount of an N-phenyl substituted 2-pyridone compound and/or pharmaceutically acceptable salts thereof.

TOPICAL ANTISEPTIC COMPOSITIONS AND METHODS

In a preferred embodiment, a method of treating bacteria, fungi, and/or viruses on the surface of, or within, the layers of the dermis of skin, ears, fingernails, toenails, or hoofs of mammalian species, comprising: applying to the surface or layers a pharmaceutical substance including an effective amount of one or more 2-(1H) pyridone compound(s).