5345-19-7

Usage

Uses

Used in Pharmaceutical Industry:
Diethyl [2-(2-nitrophenyl)ethyl]propanedioate is used as an intermediate in the synthesis of various pharmaceuticals and organic materials. Its unique chemical structure allows it to be a key component in the development of new drugs and therapeutic agents.
Used in Medicinal Applications:
Due to its strong antibacterial and antifungal properties, diethyl [2-(2-nitrophenyl)ethyl]propanedioate is used as an active ingredient in medications designed to treat infections caused by bacteria and fungi. Its effectiveness in combating these microorganisms makes it a valuable asset in the medical field.
Used in Agricultural Applications:
In agriculture, diethyl [2-(2-nitrophenyl)ethyl]propanedioate is used as a biocidal agent to protect crops from bacterial and fungal infections. Its strong antimicrobial properties help to maintain the health of plants and increase crop yields.
It is important to handle diethyl [2-(2-nitrophenyl)ethyl]propanedioate with care, as it may pose health risks if not used properly. Proper safety measures should be taken to minimize any potential hazards associated with this chemical compound.

Upstream product

• 579-71-5 2-nitrostyrene 
• 105-53-3 diethyl malonate 

Downstream Products

• 5345-24-4 bis-(2-nitro-phenethyl)-malonic acid diethyl ester 

Relevant academic research and scientific papers

Nucleophilic additions to polarized vinylarenes

The addition of nucleophiles to the terminal double bond carbon of a styrene incorporating an electron-withdrawing group at the ortho or para position has been studied. The conditions for this transformation have been optimized and structural modifications to the substrate have been explored. The structural changes included variation of the activating group on the aromatic ring and positioning substituents on the side chain double bond. The study revealed that nitro substitution gave the best results for addition of carbon and nitrogen nucleophiles. Cyano-substituted systems added carbon nucleophiles, but underwent polymerization or degradation with nitrogen nucleophiles. Ethoxycarbonyl-bearing substrates reacted primarily at the ester carbonyl. The reaction generally proceeded well with methyl on the α carbon of the double bond, but was slowed by methyl at the β position. The yields varied from 50% to 97% for 22 examples.

REGENERATION OF 2,2`-CYCLOPROPYLIDENE-BIS(OXAZOLINES)

The present invention provides a method for regeneration of chiral 2,2'-cyclopropylidene-bis(oxazolines), such as (3&R, 3'aR,8aS,8'aS )-2,2'-cyclopropylidenebis-[3a,8a]-dihydro-8H-indeno-[l,2-d]-oxazole and (45,4'5,5R,5'R )-2,2'-cyclopropylidenebis-4,5-diphenyldihydro-4,5-oxazole, used as a part of complex catalysts for e.g. stereoselective addition reactions, from the reaction mixtures, by selective sorption of 2,2'-cyclopropylidene-bis(oxazolines) on a sorbent, such as silica gel, isolation of the sorbent from reaction mixture, desorption of 2,2'-cyclopropylidene-bis(oxazolines) from the sorbent with suitable organic solvent and final recovery of 2,2'-cyclopropylidene-bis(oxazolines) from the organic solvent used for desorption process. Catalytic quality of recovered compounds does not differ from those in freshly prepared catalysts.