5345-46-0

Usage

Uses

Used in Organic Synthesis:
5-ACENAPHTHENECARBOXALDEHYDE 95 is used as a reagent in organic synthesis for the production of various organic compounds.
Used in Dye Production:
5-ACENAPHTHENECARBOXALDEHYDE 95 is used as an intermediate in the production of dyes, contributing to the development of colorants for various applications.
Used in Pharmaceutical Manufacturing:
5-ACENAPHTHENECARBOXALDEHYDE 95 is utilized in the manufacturing of pharmaceuticals, serving as a key component in the synthesis of certain drugs.
Used in Agrochemical Production:
5-ACENAPHTHENECARBOXALDEHYDE 95 is employed as an intermediate in the production of agrochemicals, aiding in the development of agricultural chemicals for crop protection and enhancement.
Used in Specialty Chemicals:
5-ACENAPHTHENECARBOXALDEHYDE 95 is used in the production of specialty chemicals, which are tailored for specific industries and applications.
Used in Materials Science:
5-ACENAPHTHENECARBOXALDEHYDE 95 is used in the field of materials science for the development of new polymers and advanced materials with unique properties, potentially contributing to innovations in various industries.

InChI:InChI=1/C13H10O/c14-8-11-7-6-10-5-4-9-2-1-3-12(11)13(9)10/h1-3,6-8H,4-5H2

Upstream product

• 74-90-8 hydrogen cyanide 
• 83-32-9 acenaphthene 
• 630-20-6 1,1,1,2-tetrachoroethane 
• 4483-79-8 chloromethylene-formamidine 
• 93-61-8 N-methyl-N-phenylformamide 
• 77144-97-9 1,3-bis-(trifluoroacetyl)-2-(5-acenaphthyl)-4-imidazoline 
• 68-12-2 N,N-dimethyl-formamide 
• 95-50-1 1,2-dichloro-benzene 
• 10025-87-3 trichlorophosphate 
• 7446-70-0 aluminium trichloride 
• 132407-64-8 trifluoromethanesulphonyloxy-methylene-N,N-dimethyliminium trifluoromethanesulphonate 

Downstream Products

• 2346-72-7 5-(1-hydroxyethyl)acenaphthene 
• 55720-24-6 Aethyl--carbinol 
• 102077-51-0 1-acenaphthen-5-yl-2-phenyl-ethanol 
• 103036-02-8 cis-1--2--ethylen-carbonsaeure-(1) 
• 107641-27-0 [1-Acenaphthen-5-yl-meth-(E)-ylidene]-(4-chloro-phenyl)-amine 
• 107641-26-9 acenaphthen-5-ylmethylen-aniline 
• 120901-73-7 5-(1,2-dihydro-5-acenaphthylenyl)-4,5-dihydro-3-phenyl-1H-pyrazole 
• 120870-22-6 N-[4-(5-Acenaphthen-5-yl-3-phenyl-4,5-dihydro-pyrazole-1-sulfonyl)-phenyl]-acetamide 

Relevant academic research and scientific papers

Design, Synthesis, and Biological Evaluation of Mitochondria-Targeted Flavone-Naphthalimide-Polyamine Conjugates with Antimetastatic Activity

Approximately 90% of cancer-associated deaths result from disseminated tumors, indicating the ineffectiveness of current therapies and the imperative need of antimetastatic drugs. A novel pharmacophore with flavonoid and naphthalimide moieties was constructed by using a fragment-based drug design and a series of eight flavone-naphthalimide-polyamine conjugates were synthesized. In vitro evaluation revealed that compound 6c with a homospermidine motif displayed better cell selectivity between cancerous and normal liver cells than amonafide did. The in vivo assays on two hepatocellular carcinoma (HCC) models verified that 6c potently suppressed pulmonary metastasis with improved organ indexes compared to amonafide. Various experiments showed that 6c as a potential fluorescent chemical probe could target the mitochondria. Preliminary investigation into the mechanism of action of 6c indicated that it might harness a polyamine transporter for cell entrance, localize in the mitochondria, selectively cause reactive oxygen species (ROS) overproduction in hepatoma cells instead of normal liver cells, and finally lead to HCC cell apoptosis and migration inhibition via multiple ROS-mediated signaling pathways.

Naphthalimide-substituted flavonoid-polyamine conjugates, and preparation method and application thereof

The invention belongs to the technical field of medicinal chemistry, and particularly relates to naphthalimide-substituted flavonoid-polyamine conjugates, and a preparation method and application thereof. According to the naphthalimide-substituted flavonoid-polyamine conjugates, and the preparation method and the application thereof, a new naphthalimide-substituted flavonoid pharmacophore is synthesized by taking benzo-gamma-pyrone as a raw material and introducing an active group naphthalimide skeleton to a 2-site of the benzo-gamma-pyrone; the new naphthalimide-substituted flavonoid pharmacophore is modified by a polyamine chain; the compound remains the activity of naphthalimide compounds, and meanwhile, has the characteristic of low toxicity of flavonoid compounds, improves the biological activity of original molecules and improves the anti-tumour activity of target molecules; and experimental verification discovers that the conjugates provided by the invention show obvious inhibiting activity to the proliferation of a plurality of tumour cells, namely, HCT-116, HepG2, Hela and SMMC7721.

A reactive cysteine probe and its preparation method (by machine translation)

The invention discloses a reactive cysteine probe and its preparation method, in order to rhodamine derivative is a fluorophore, acrylic ester structure is a cysteine specific reactive group; probe itself fluorescence is extremely weak, strong fluorescent after reaction with cysteine, can be used for detection of the cysteine. The probe in PBS 7.4 (30% ethanol) system in half-cystine reaction is more rapid, has good selectivity and higher sensitivity; can be used to determine in biological and environmental system of the cysteine content of the fluorescence detection, visual qualitative detection, cell imaging detection. (by machine translation)

Rhodamine fluorescence dye and preparation method thereof

The invention discloses a rhodamine fluorescence dye and a preparation method thereof. A classic rhodamine synthesis method is used as a basis, chemical groups having different functions are introduced to a rhodamine parent through reasonable structural modification, a conjugative effect is added, and hyperchromic groups, such as hydroxy, diethylin and azabicyalo, are changed. The prepared novel rhodamine fluorescence dye has a larger emission wavelength and higher light quantum yield and also has more reaction loci, so that follow-up reaction is more convenient. In addition, the rhodamine fluorescence dye has appropriate Stokes shift, and wavelength interference excitation can be avoided in follow-up fluorescence detection, so that analysis results are more accurate.

Reactive sulfhydryl compound probe and preparation method thereof

The invention discloses a reactive sulfhydryl compound probe and a preparation method of the probe. A sensing molecule releases a rhodamine dye molecule monomer based on a thiol participated disulfide bond cleavage reaction, the fluorescence intensity is significantly improved, an obvious color change is accompanied, and selected interfering ions and the like almost have no influence on a detection effect, so that specific recognition response to a sulfhydryl compound is realized, and a detection limit reaches 0.124 micrometers.

Benzopyran-4-one substituted naphthalimide-polyamine conjugate and preparing method and usage thereof

The invention relates to a benzopyran-4-one substituted naphthalimide-polyamine conjugate and a preparing method and usage thereof. The naphthalimide-polyamine conjugate has a structure as shown in a formula I. The benzopyran-4-one substituted naphthalimide-polyamine conjugate has obvious inhibition activity for cell proliferation of multiple tumor cells such as HCT-116 (human colon cancer cell), HepG2 (human hepatoma carcinoma cell), K562 (human chronic myeloid leukemia cells) and SMMC7721 (human hepatoma carcinoma cell); the conjugate can also serve as a targeting mitochondria fluorescence probe and can effectively inhibit pulmonary metastasis of the tumor, wherein a is 0, 1 or 2, m is 1, 2 or 3, n is 1, 2, 3, or 4, R is H or CH3, and R1 is shown in the description.

A useful scaffold based on acenaphthene exhibiting Cu2+ induced excimer fluorescence and sensing cyanide via Cu2+ displacement approach

A new simple organic scaffold based on acenaphthene 4 was designed and synthesized. The chromogenic and fluorogenic properties of 4 toward different metal ions and anions were investigated in H2O/MeCN (8:2, v/v) solution. The probe 4 in the pre

A New Procedure for Formylation of Less Active Aromatics

The formylation of aromatic compounds with trifluoromethanesulphonic anhydride/dimethylformamide complex 2 takes place easily as compared to the normal Vilsmeier-Haack reaction.