53464-60-1

Upstream product

• 1499-55-4 L-glutamic acid 5-methyl ester 
• 197151-79-4 pteroyl azide 
• 6674-22-2 1,8-diazabicyclo[5.4.0]undec-7-ene 
• 223378-68-5 N¹⁰-(trifluoroacetyl)pyrofolic acid 
• 223378-69-6 pyrofolic acid 
• 197151-80-7 N¹⁰-nitrosopteroyl azide 
• 197151-68-1 pteroyl hydrazide 
• 59-30-3 folic acid 

Downstream Products

• 197151-85-2 N²-(4-(((2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl)amino)benzoyl)-N⁵-(2-aminoethyl)-L-glutamine 

Relevant academic research and scientific papers

Novel compositions magnetic particles covered with gem-bisphosphonate derivatives

The invention relates to a composition comprising acid magnetic particles (p) based on an iron compound, the acid magnetic particles (p) being complexed by one or more gem-bisphosphonate compounds, of formula I: [in-line-formulae]X-L-CH(PO3H2)2 ??(I)[/in-line-formulae]in which: L represents an organic group connecting the X group to the gem-bisphosphonate group —CH(PO3H2)2;X represents a chemical group capable of reacting with a biovector; all or some of the X groups of the particles optionally being coupled to a biovector. The invention relates also to a process for the preparation of the compositions and their use, in particular as contrast products for Magnetic Resonance Imaging (MRI).

Folate-modified cholesterol-bearing pullulan as a drug carrier

Folate modified cholesterol-bearing pullulan (FA-CHP) was synthesized by the reaction of folic acid γ-2-aminoethylamide and 4-nitorophenyl chloroformate-activated cholesterol-bearing pullulan, wherein folate and pullulan are connected through a NH—CH

Efficient syntheses of pyrofolic acid and pteroyl azide, reagents for the production of carboxyl-differentiated derivatives of folic acid

Reaction of folic acid (1) with excess trifluoroacetic anhydride provides access to both the previously unknown N10-(trifluoroacetyl)pyrrofolic acid (8) and pyrofolic acid (9). Reaction of either of these materials with hydrazine selectively affords pteroyl hydrazide (13), which may be oxidized to pteroyl azide (27) on a large scale (62% overall from I without the need for chromatography). Treatment of 27 with differentially protected glutamates provides a convenient and high-yielding synthesis of differentially protected, optically pure folates.