197151-85-2

Basic information

• Product Name: N²-(4-(((2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl)amino)benzoyl)-N⁵-(2-aminoethyl)-L-glutamine
• Synonyms: N²-(4-(((2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl)amino)benzoyl)-N⁵-(2-aminoethyl)-L-glutamine
• CAS NO: 197151-85-2
• Molecular Weight: 483.487
• Mol File: 197151-85-2.mol
• Article Data: 22

Chemical Properties

• CAS DataBase Reference: N²-(4-(((2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl)amino)benzoyl)-N⁵-(2-aminoethyl)-L-glutamine(CAS DataBase Reference)
• NIST Chemistry Reference: N²-(4-(((2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl)amino)benzoyl)-N⁵-(2-aminoethyl)-L-glutamine(197151-85-2)
• EPA Substance Registry System: N²-(4-(((2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl)amino)benzoyl)-N⁵-(2-aminoethyl)-L-glutamine(197151-85-2)

Safety Data

• Hazardous Substances Data: 197151-85-2(Hazardous Substances Data)

Upstream product

• 107-15-3 ethylenediamine 
• 153445-05-7 folic acid, N-hydroxysuccinimide ester 
• 197151-79-4 pteroyl azide 
• 197151-68-1 pteroyl hydrazide 
• 59-30-3 (S)-2-(4-(((2-amino-4-hydroxypteridin-6-yl)methyl)amino)benzamido)pentanedioic acid 
• 1049627-30-6 C₃₀H₄₁N₉O₇ 
• 153445-05-7 N-hydroxysuccinimide folate 
• 84793-07-7 Fmoc-Glu-OtBu 
• 37793-53-6 N¹⁰-(trifluoroacetyl)pteroic acid 
• 910661-25-5 (S)-tert-butyl 2-amino-5-(2-(tert-butoxycarbonylamino)ethylamino)-5-oxopentanoate 
• 910661-24-4 (S)-tert-butyl 2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-5-(2-(tert-butoxycarbonylamino)ethylamino)-5-oxopentanoate 
• 1017018-99-3 C₂₆H₃₃N₉O₇ 
• 53464-60-1 L-methyl folate (γ) 
• 223378-68-5 N¹⁰-(trifluoroacetyl)pyrofolic acid 

Downstream Products

• 1608495-97-1 C₃₉H₄₄N₁₂O₇ 
• 1579248-68-2 folate-EDA-EDTA-Cys-OH 
• 1579248-67-1 folate-EDA-EDTA-Cys(Trt)-OH 

Relevant articles and documents

Development of 99mTc-labeled trivalent isonitrile radiotracer for folate receptor imaging

Folate receptors (FR) are frequently overexpressed in a wide variety of human cancers. The aim of this study was to develop a trivalent 99mTc(CO)3-labeled folate radiotracer containing isonitrile (CN-R) as the coordinating ligand for

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A folate-conjugated platinum porphyrin complex as a new cancer-targeting photosensitizer for photodynamic therapy

A new folate-conjugated platinum porphyrin complex (Por 4) was synthesized and characterized. The singlet oxygen production of the conjugates was evaluated through a 1,3-diphenylisobenzofuran method. The targeting ability and subcellular localization of P

Synthesis of a functionalized dipeptide for targeted delivery and pH-sensitive release of chemotherapeutics

Targeted delivery of chemotherapeutics to tumor cells is one of the biggest challenges in cancer treatment. Herein, we synthesized smart dipeptide nanoparticles for cancer-specific targeting and intracellular pH-sensitive release of chemotherapeutics. Diphenylalanine peptide was synthesized and further developed as nanoparticles (NPs), which were functionalized with folic acid utilizing the carbodiimide reaction. Doxorubicin (Dox) was loaded to self-assembled non-functionalized (FF-Dox) and folate functionalized peptides NPs (FA-FF-Dox). Moreover, the experiments revealed the pH-sensitive release of Dox for both FA-FF-Dox and FF-Dox due to the protonation of the Schiff base and the amines present in the peptides at low pH, enhancing intracellular release subsequent to receptor-mediated endocytosis. Further, biodistribution and the pharmacokinetics study revealed enhanced targeting efficiency of FA-FF-Dox with high accumulation in tumor cells.