5350-81-2

Basic information

• Product Name: tert-butyl diphenylacetate
• CAS NO: 5350-81-2
• Molecular Formula: C₁₈H₂₀O₂
• Molecular Weight: 268.3502
• Mol File: 5350-81-2.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 356.8°C at 760 mmHg
• Flash Point: 124°C
• Density: 1.049g/cm³
• Vapor Pressure: 2.84E-05mmHg at 25°C
• Refractive Index: 1.542
• CAS DataBase Reference: tert-butyl diphenylacetate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl diphenylacetate(5350-81-2)
• EPA Substance Registry System: tert-butyl diphenylacetate(5350-81-2)

Safety Data

• Hazardous Substances Data: 5350-81-2(Hazardous Substances Data)

Upstream product

• 1871-76-7 diphenylacetic acid chloride 
• 75-65-0 tert-butyl alcohol 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 540-88-5 acetic acid tert-butyl ester 
• 13144-32-6 diphenylacetyl tert-butyl perester 
• 117-34-0 2,2-diphenylacetic acid 
• 2996-92-1 phenyl trimethylsiloxane 
• 72410-67-4 tert-butyl 2-diazo-2-phenylacetate 
• 83766-88-5 2-tert-butoxypyridine 
• 134-81-6 benzil 
• 98946-18-0 tert-Butyl 2,2,2-trichloroacetimidate 
• 98-80-6 phenylboronic acid 
• 525-06-4 diphenyl ketene 
• 57369-76-3 diphenylacetyl bromide 

Downstream Products

• 54075-39-7 N'-(2-tert.-Butoxyethyl)-N,N-diphenylharnstoff 
• 77236-61-4 <2-(3,3-Diphenylureido)ethoxy>diphenylessigsaeure-tert-butylester 
• 1871-76-7 diphenylacetic acid chloride 
• 1733-63-7 1,2,2-triphenylethan-1-one 
• 938-16-9 2,2-dimethylpropiophenone 
• 781-35-1 1,1-diphenylacetone 

Relevant articles and documents

Photoredox Catalytic Phosphite-Mediated Deoxygenation of α-Diketones Enables Wolff Rearrangement and Staudinger Synthesis of β-Lactams

A novel visible-light-driven catalytic activation of C=O bonds by exploiting the photoredox chemistry of 1,3,2-dioxaphospholes, readily accessible from α-diketones and trialkyl phosphites, is reported. This mild and environmentally friendly strategy provides an unprecedented and efficient access to the Wolff rearrangement reaction which traditionally entails α-diazoketones as precursors. The resulting ketenes could be precisely trapped by alcohols/thiols to give α-aryl (thio)acetates and by imines to afford the valuable β-lactams in up to 99 % yields.

A fast and practical synthesis of tert-butyl esters from 2-tert-butoxypyridine using boron trifluoride·diethyl etherate under mild conditions

A practical direct preparation of tert-butyl esters from 2-tert-butoxypyridine has been developed. This system features the use of boron trifluoride·diethyl etherate in toluene solvent to rapidly achieve the reaction at room temperature. Using this reaction protocol, a variety of tert-butyl esters were synthesized from several different carboxylic acids at high yields. This practical procedure provides a promising and effective approach to the protection of carboxylic acids with a tert-butyl group.

Rh(I)-catalyzed cross-coupling of α-diazoesters with arylsiloxanes

An Rh(I)-catalyzed cross-coupling of diazoesters with arylsiloxanes has been successfully achieved. This transformation is a new method for the construction of the C(sp3)-C(sp2) bond, thus providing an alternative synthesis of α-aryl esters. Rh(I)-carbene migratory insertion has been proposed to be involved in this coupling reaction. The reaction represents the first example of utilizing arylsiloxane as the coupling partner in the carbene-involved cross-coupling reactions.